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Synthesis of 6β-N(5)-Methyl-5,6,7,8-tetrahydro-L-biopterin


Bosshard, Rene; Heizmann, Claus W; Viscontini, Max (1993). Synthesis of 6β-N(5)-Methyl-5,6,7,8-tetrahydro-L-biopterin. Pteridines, 4(3):115-118.

Abstract

Summary 6β-N(5)-methyl-5.6J,8-tetrahydro-L-biopterin·2 HC1. a new derivate of biological interest, was synthesized from 6β-5,6,7,8-tetrahydro-L-biopteril·2 HC1 and characterized. The latter compound has been used therapeutically in atypical phenylketonuria for many years. The catalytic reductive methylation with PtO2 /H2 and formaldehyde allowed selective methylation at the N(5) position. The chemical properties and stnlctures of the new compound arc compared with N(5)-methyl-tetrahydropterin and N(5)-methyl-tetrahydrofolate

Abstract

Summary 6β-N(5)-methyl-5.6J,8-tetrahydro-L-biopterin·2 HC1. a new derivate of biological interest, was synthesized from 6β-5,6,7,8-tetrahydro-L-biopteril·2 HC1 and characterized. The latter compound has been used therapeutically in atypical phenylketonuria for many years. The catalytic reductive methylation with PtO2 /H2 and formaldehyde allowed selective methylation at the N(5) position. The chemical properties and stnlctures of the new compound arc compared with N(5)-methyl-tetrahydropterin and N(5)-methyl-tetrahydrofolate

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Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:Unspecified
Scopus Subject Areas:Life Sciences > Biochemistry
Life Sciences > Molecular Medicine
Life Sciences > Clinical Biochemistry
Language:English
Date:1 January 1993
Deposited On:16 Oct 2018 12:54
Last Modified:15 Apr 2020 21:07
Publisher:De Gruyter
ISSN:0933-4807
OA Status:Green
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1515/pteridines.1993.4.3.115
Related URLs:https://www.swissbib.ch/Search/Results?lookfor=nationallicencegruyter101515pteridines199343115 (Library Catalogue)

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