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Endocrine Disorders as a Contributory Factor to Neoplasia in SJL/J Mice2


Pierpaoli, W; Haran-Ghera, N; Bianchi, E; Müller, J; Meshorer, A; Bree, M (1974). Endocrine Disorders as a Contributory Factor to Neoplasia in SJL/J Mice2. Journal of the National Cancer Institute, 53(3):731-744.

Abstract

We studied the endocrine status of SJL/J mice. Light and electron microscopy revealed that the adenohypophyses of both sexes became progressively infiltrated with an abnormal number of gonadotropinproducing cells that probably secreted large amounts of luteotropic hormone. The ovaries had numerous large corpora lutea even in animals over 1 year of age with reticulum cell neoplasms. The adrenal cortexes of female mice showed no regression of the reticular zone. In accordance with the anomalous condition of the adenohypophysis and ovary, females had abnormal estrous cycles, with prolonged diestrus and consequent reduction in fertility. These data were discussed in the context of hormone environment versus onset of systemic neoplastic disease and the relationship between hormone dependence and leukemic virus expression

Abstract

We studied the endocrine status of SJL/J mice. Light and electron microscopy revealed that the adenohypophyses of both sexes became progressively infiltrated with an abnormal number of gonadotropinproducing cells that probably secreted large amounts of luteotropic hormone. The ovaries had numerous large corpora lutea even in animals over 1 year of age with reticulum cell neoplasms. The adrenal cortexes of female mice showed no regression of the reticular zone. In accordance with the anomalous condition of the adenohypophysis and ovary, females had abnormal estrous cycles, with prolonged diestrus and consequent reduction in fertility. These data were discussed in the context of hormone environment versus onset of systemic neoplastic disease and the relationship between hormone dependence and leukemic virus expression

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Oncology
Life Sciences > Cancer Research
Language:English
Date:1 September 1974
Deposited On:01 Nov 2018 13:42
Last Modified:31 Jul 2020 02:18
Publisher:Oxford University Press
ISSN:0027-8874
OA Status:Green
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1093/jnci/53.3.731
Related URLs:https://www.swissbib.ch/Search/Results?lookfor=nationallicenceoxford101093jnci533731 (Library Catalogue)

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