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Drug monographs on drugs which are frequently analysed in the context of Therapeutic Drug Monitoring / Arzneimittel-Monographien für Medikamente, die regelmäßig im Rahmen des Therapeutic Drug Monitorings analysiert werden


Rentsch, Katharina; Baumann, Pierre; Fathi, Marc; Grignaschi, Nathalie; Magnin, Jean-Luc; Thormann, Wolfgang; Todesco, Liliane; Wenk, Markus; Werner, Dominique (2006). Drug monographs on drugs which are frequently analysed in the context of Therapeutic Drug Monitoring / Arzneimittel-Monographien für Medikamente, die regelmäßig im Rahmen des Therapeutic Drug Monitorings analysiert werden. Journal of Laboratory Medicine, 30(6):443-452.

Abstract

In addition to the monographs which were published last year by the working group "Drug Monitoring” of the Swiss Society of Clinical Chemistry (SSCC) [1], new monographs have been written. The aim of these monographs is to give an overview of the most important information necessary for ordering a drug analysis or interpreting the results. Therefore, the targeted readers comprise laboratory health professionals and all receivers of laboratory reports. There is information provided on the indication for therapeutic drug monitoring, protein binding, metabolic pathways and enzymes involved, elimination half-life and elimination routes, and on therapeutic or toxic concentrations. Preanalytical considerations are of particular importance for therapeutic drug monitoring. Therefore, information is provided regarding a reasonable timing for the determination of drug concentrations as well as steady-state concentrations after changing the dose. Furthermore, the stability of the drug and its metabolite(s) after blood sampling is described. For readers with a specific interest in drug analysis, references to important publications are given. The number of monographs will be continuously enlarged. The updated files are presented on the homepage of the SSCC (www.sscc.ch). We hope that these monographs are helpful and look forward to receiving comments from the audience

Abstract

In addition to the monographs which were published last year by the working group "Drug Monitoring” of the Swiss Society of Clinical Chemistry (SSCC) [1], new monographs have been written. The aim of these monographs is to give an overview of the most important information necessary for ordering a drug analysis or interpreting the results. Therefore, the targeted readers comprise laboratory health professionals and all receivers of laboratory reports. There is information provided on the indication for therapeutic drug monitoring, protein binding, metabolic pathways and enzymes involved, elimination half-life and elimination routes, and on therapeutic or toxic concentrations. Preanalytical considerations are of particular importance for therapeutic drug monitoring. Therefore, information is provided regarding a reasonable timing for the determination of drug concentrations as well as steady-state concentrations after changing the dose. Furthermore, the stability of the drug and its metabolite(s) after blood sampling is described. For readers with a specific interest in drug analysis, references to important publications are given. The number of monographs will be continuously enlarged. The updated files are presented on the homepage of the SSCC (www.sscc.ch). We hope that these monographs are helpful and look forward to receiving comments from the audience

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Additional indexing

Contributors:Working group “Drug Monitoring” of the SSCC (Arbeitsgruppe Medikamente der SGKC)
Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:Unspecified
Language:English
Date:1 January 2006
Deposited On:02 Nov 2018 06:59
Last Modified:02 Nov 2018 21:17
Publisher:De Gruyter
ISSN:2567-9430
OA Status:Green
Publisher DOI:https://doi.org/10.1515/jlm.2006.049
Related URLs:https://www.swissbib.ch/Search/Results?lookfor=nationallicencegruyter101515JLM2006049 (Library Catalogue)

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