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Monographs on drugs which are frequently analyzed in therapeutic drug monitoring


Rentsch, K; Buhl, Daniela; Eap, Chin Bin; Fathi, Marc; Jöchle, Wolfgang; Magnin, Jean-Luc; Thormann, Wolfgang; Werner, Dominique; Working group “Drug Monitoring” of the SSCC (2010). Monographs on drugs which are frequently analyzed in therapeutic drug monitoring. Journal of Laboratory Medicine, 34(3):129-139.

Abstract

In addition to the monographs which have been published in the past 4 years by the working group "Drug Monitoring” of the Swiss Society of Clinical Chemistry (SSCC) [1-4], new monographs have been written. The data presented in these monographs provide an overview of important information for the request and interpretation of results. Therefore, laboratory health professionals and the receivers of the reports are the targeted readers. In this series, several antiepileptic drugs are presented. Monographs on carbamazepine [1], lamotrigine [2], phenobarbital [2], and valproic acid [2] have been published previously. First, information about pharmacology and pharmacokinetics of these drugs (protein binding, metabolic pathways and enzymes involved, elimination half-life time and elimination route(s) of the parent drug and therapeutic as well as toxic concentrations) is given. Second, the indications for therapeutic drug monitoring are listed. Last but not least, important pre-analytical information is provided, including time points of blood sampling and time interval after which steady-state concentrations are reached after changing the dose. Furthermore, the stability of the drug and its metabolite(s) after blood sampling is described. For readers with a specific interest, references to important publications are given. The number of the monographs will be further enlarged. The updated files are presented on the homepage of the SSCC (www.sscc.ch). We hope that these monographs are helpful for the better handling of therapeutic drug monitoring and we are looking forward to comments from the readers

Abstract

In addition to the monographs which have been published in the past 4 years by the working group "Drug Monitoring” of the Swiss Society of Clinical Chemistry (SSCC) [1-4], new monographs have been written. The data presented in these monographs provide an overview of important information for the request and interpretation of results. Therefore, laboratory health professionals and the receivers of the reports are the targeted readers. In this series, several antiepileptic drugs are presented. Monographs on carbamazepine [1], lamotrigine [2], phenobarbital [2], and valproic acid [2] have been published previously. First, information about pharmacology and pharmacokinetics of these drugs (protein binding, metabolic pathways and enzymes involved, elimination half-life time and elimination route(s) of the parent drug and therapeutic as well as toxic concentrations) is given. Second, the indications for therapeutic drug monitoring are listed. Last but not least, important pre-analytical information is provided, including time points of blood sampling and time interval after which steady-state concentrations are reached after changing the dose. Furthermore, the stability of the drug and its metabolite(s) after blood sampling is described. For readers with a specific interest, references to important publications are given. The number of the monographs will be further enlarged. The updated files are presented on the homepage of the SSCC (www.sscc.ch). We hope that these monographs are helpful for the better handling of therapeutic drug monitoring and we are looking forward to comments from the readers

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Additional indexing

Other titles:Arzneimittel-Monographien für Medikamente, die regelmäßig im Rahmen des Therapeutic Drug Monitorings analysiert werden
Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:Unspecified
Uncontrolled Keywords:antiepileptics; clonazepam; ethosuximide; gabapentine; levetiracetam; oxcarbazepine; phenytoin; primidone; topiramate; vigabatrin; Antiepileptika; Clonazepam; Ethosuximid; Gabapentin; Levetiracetam; Oxcarbazepin; Phenytoin; Primidon; Topiramat; Vigabatrin
Language:English
Date:1 January 2010
Deposited On:06 Nov 2018 17:56
Last Modified:07 Nov 2018 16:37
Publisher:De Gruyter
ISSN:2567-9430
OA Status:Green
Publisher DOI:https://doi.org/10.1515/jlm.2010.024
Related URLs:https://www.swissbib.ch/Search/Results?lookfor=nationallicencegruyter101515jlm2010024 (Library Catalogue)

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