Header

UZH-Logo

Maintenance Infos

Consequences of different diagnostic ‘gold standards’ in test accuracy research: Carpal Tunnel Syndrome as an example


Bachmann, Lucas M; Jüni, Peter; Reichenbach, Stephan; Ziswiler, Hans-Rudolf; Kessels, Alfons G; Vögelin, Esther (2005). Consequences of different diagnostic ‘gold standards’ in test accuracy research: Carpal Tunnel Syndrome as an example. International Journal of Epidemiology, 34(4):953-955.

Abstract

Test accuracy studies assume the existence of a well-defined illness definition and clear-cut diagnostic gold standards or reference standards. However, in clinical reality illness definitions may be vague or a mere description of a set of manifestations, mostly clinical signs and symptoms. This can lead to disagreements among experts about the correct classification of an illness and the adequate reference standard. Using data from a diagnostic accuracy study in carpal tunnel syndrome, we explored the impact of different definitions on the estimated test accuracy and found that estimated test performance characteristics varied considerably depending on the chosen reference standard. In situations without a clear-cut illness definition, randomized controlled trials may be preferable to test accuracy studies for the evaluation of a novel test. These studies do not determine the diagnostic accuracy, but the clinical impact of a novel test on patient management and outcome

Abstract

Test accuracy studies assume the existence of a well-defined illness definition and clear-cut diagnostic gold standards or reference standards. However, in clinical reality illness definitions may be vague or a mere description of a set of manifestations, mostly clinical signs and symptoms. This can lead to disagreements among experts about the correct classification of an illness and the adequate reference standard. Using data from a diagnostic accuracy study in carpal tunnel syndrome, we explored the impact of different definitions on the estimated test accuracy and found that estimated test performance characteristics varied considerably depending on the chosen reference standard. In situations without a clear-cut illness definition, randomized controlled trials may be preferable to test accuracy studies for the evaluation of a novel test. These studies do not determine the diagnostic accuracy, but the clinical impact of a novel test on patient management and outcome

Statistics

Citations

Dimensions.ai Metrics
31 citations in Web of Science®
31 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

22 downloads since deposited on 23 Oct 2018
8 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Epidemiology
Language:English
Date:1 August 2005
Deposited On:23 Oct 2018 12:46
Last Modified:15 Apr 2021 14:50
Publisher:Oxford University Press
ISSN:0300-5771
OA Status:Hybrid
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1093/ije/dyi105

Download

Hybrid Open Access

Download PDF  'Consequences of different diagnostic ‘gold standards’ in test accuracy research: Carpal Tunnel Syndrome as an example'.
Preview
Content: Published Version
Language: English
Filetype: PDF (Nationallizenz 142-005)
Size: 72kB
View at publisher