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Regulation of Aldosterone Biosynthesis: A Continual Challenge


Muller, J; Lauber, M (1991). Regulation of Aldosterone Biosynthesis: A Continual Challenge. American Journal of Hypertension, 4(3 Pt 1):280-282.

Abstract

Aldosterone secretion by the zona glomerulosa of the adrenal cortex is directly influenced by a large, growing number of different physiologic agents. Their action includes: 1) acute stimulation or inhibition of early biosynthetic steps; 2) long-term activation or suppression of late biosynthetic steps; and 3) induction of growth or atrophy of zona glomerulosa cells. In rats, adaptation of late steps of aldosterone biosynthesis to sodium and potassium intake is mediated by the induction or repression of a second form of cytochrome P-45011β, which differs from the main form of t h e enzyme b y a lower molecular weight and a greater range of catalytic properties. Am J Hypertens 1991;4:280-282

Abstract

Aldosterone secretion by the zona glomerulosa of the adrenal cortex is directly influenced by a large, growing number of different physiologic agents. Their action includes: 1) acute stimulation or inhibition of early biosynthetic steps; 2) long-term activation or suppression of late biosynthetic steps; and 3) induction of growth or atrophy of zona glomerulosa cells. In rats, adaptation of late steps of aldosterone biosynthesis to sodium and potassium intake is mediated by the induction or repression of a second form of cytochrome P-45011β, which differs from the main form of t h e enzyme b y a lower molecular weight and a greater range of catalytic properties. Am J Hypertens 1991;4:280-282

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:Unspecified
Scopus Subject Areas:Health Sciences > Internal Medicine
Language:English
Date:1 March 1991
Deposited On:16 Oct 2018 15:16
Last Modified:15 Apr 2021 14:50
Publisher:Oxford University Press
ISSN:0895-7061
OA Status:Green
Publisher DOI:https://doi.org/10.1093/ajh/4.3.280

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