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On the role of viruses in the evolution of immune responses


Zinkernagel, R M; Hengartner, H; Stitz, L (1985). On the role of viruses in the evolution of immune responses. British Medical Bulletin, 41(1):92-97.

Abstract

Mutual influences of viruses on the immune system and vice versa which lead to a biological balance are considered, with clinical and/or experimental findings. Numbers and turnover of immune cells can be correlated with numbers and growth rate of viruses; certain viruses apparently have adapted to systemic or local immune effector mechanisms. The biological balance of viruses and immune system guarentees overall protection of both host and parasite. It alos may lead to conditions where immune protective mechanisms causes cell and tissue damage leading to disease. Immunologically mediated disease may be influenced by immune regulation via HLA antigen and may therefore explain HLA-disease associations. Finally, the different specificities of antibodies vs. T Cells and the differing kinetics of their immunological memory are outlined and correlated with immune escape, immune protection and the resulting possible evolutionary pressures on viruses

Abstract

Mutual influences of viruses on the immune system and vice versa which lead to a biological balance are considered, with clinical and/or experimental findings. Numbers and turnover of immune cells can be correlated with numbers and growth rate of viruses; certain viruses apparently have adapted to systemic or local immune effector mechanisms. The biological balance of viruses and immune system guarentees overall protection of both host and parasite. It alos may lead to conditions where immune protective mechanisms causes cell and tissue damage leading to disease. Immunologically mediated disease may be influenced by immune regulation via HLA antigen and may therefore explain HLA-disease associations. Finally, the different specificities of antibodies vs. T Cells and the differing kinetics of their immunological memory are outlined and correlated with immune escape, immune protection and the resulting possible evolutionary pressures on viruses

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Scopus Subject Areas:Health Sciences > General Medicine
Language:English
Date:1 January 1985
Deposited On:18 Oct 2018 10:52
Last Modified:15 Apr 2021 14:50
Publisher:Oxford University Press
ISSN:0007-1420
OA Status:Green
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1093/oxfordjournals.bmb.a072033

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