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The 825C/T polymorphism of the G‐protein subunit β3 does not influence blood pressure and renal function in kidney transplant recipients


Wüthrich, Rudolf P; Cicvara, Snjezana; Booy, Christa; Widmer, Urs; Binswanger, Ulrich (2000). The 825C/T polymorphism of the G‐protein subunit β3 does not influence blood pressure and renal function in kidney transplant recipients. Nephrology, Dialysis, Transplantation, 15(10):1663-1666.

Abstract

Background. Recently, a polymorphism at position 825 (C→T) of the cDNA that encodes the β3 subunit of heterotrimeric G proteins (Gβ3) was found to be associated with essential hypertension. The T allele leads to the formation of a truncated splice variant (Gβ3‐s) with enhanced activity, promoting hypertension. We examined whether the T allele had an influence on blood pressure (BP) and early renal function after renal transplantation. Methods. We determined the Gβ3 genotype and T allele frequencies in renal transplant patients and examined associations with BP, BP medications, and renal function in the first year after transplantation. Results. In renal transplant recipients (n=216) the frequency of the T allele was marginally increased (0.34 vs 0.29) compared with normal healthy blood donors (n=163). Age, sex and body mass index were similar in patients with the CC, CT and TT genotype. BP, number of BP medications, and serum creatinine levels were also similar for the three genotypes within the first year after transplantation. Significantly more patients with the TT genotype (48%) had glomerulonephritis as the underlying renal disease, compared with the CT (29%) and CC (27%) genotypes. Conclusions. The T allele of Gβ3 does not have a negative impact on BP and early renal function in recipients of a renal allograft. The T allele might play a role in the pathogenesis of chronic glomerulonephritides

Abstract

Background. Recently, a polymorphism at position 825 (C→T) of the cDNA that encodes the β3 subunit of heterotrimeric G proteins (Gβ3) was found to be associated with essential hypertension. The T allele leads to the formation of a truncated splice variant (Gβ3‐s) with enhanced activity, promoting hypertension. We examined whether the T allele had an influence on blood pressure (BP) and early renal function after renal transplantation. Methods. We determined the Gβ3 genotype and T allele frequencies in renal transplant patients and examined associations with BP, BP medications, and renal function in the first year after transplantation. Results. In renal transplant recipients (n=216) the frequency of the T allele was marginally increased (0.34 vs 0.29) compared with normal healthy blood donors (n=163). Age, sex and body mass index were similar in patients with the CC, CT and TT genotype. BP, number of BP medications, and serum creatinine levels were also similar for the three genotypes within the first year after transplantation. Significantly more patients with the TT genotype (48%) had glomerulonephritis as the underlying renal disease, compared with the CT (29%) and CC (27%) genotypes. Conclusions. The T allele of Gβ3 does not have a negative impact on BP and early renal function in recipients of a renal allograft. The T allele might play a role in the pathogenesis of chronic glomerulonephritides

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Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:1 October 2000
Deposited On:25 Sep 2018 14:22
Last Modified:04 Oct 2018 11:37
Publisher:Oxford University Press
ISSN:0931-0509
OA Status:Green
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1093/ndt/15.10.1663
Related URLs:https://www.swissbib.ch/Search/Results?lookfor=nationallicenceoxford101093ndt15101663 (Library Catalogue)

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