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Distribution and kinetics of 14 c-vecuronium in rats and mice


Waser, P G; et al, (1987). Distribution and kinetics of 14 c-vecuronium in rats and mice. British Journal of Anaesthesia, 59(8):1044-1051.

Abstract

The distribution and kinetics of 14C-vecuronium were studied in rats and mice. 14C-Vecuronium accumulated rapidly in the liver. Both unchanged and metabolized vecuronium were excreted with the bile into the intestines and stomach. Reabsorption in the gut was probably responsible for an enterohepatic increase in radioactivity in the liver after one hour. Excretion through the kidneys increased continuously from low values after the initial peak. Binding in compartments with acid mucopolysaccharides such as cartilage, connective tissue etc., was less important. Bloodbrain barrier and placenta were permeable only to a small degree

Abstract

The distribution and kinetics of 14C-vecuronium were studied in rats and mice. 14C-Vecuronium accumulated rapidly in the liver. Both unchanged and metabolized vecuronium were excreted with the bile into the intestines and stomach. Reabsorption in the gut was probably responsible for an enterohepatic increase in radioactivity in the liver after one hour. Excretion through the kidneys increased continuously from low values after the initial peak. Binding in compartments with acid mucopolysaccharides such as cartilage, connective tissue etc., was less important. Bloodbrain barrier and placenta were permeable only to a small degree

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:610 Medicine & health
Uncontrolled Keywords:Anesthesiology and Pain Medicine
Language:English
Date:1 August 1987
Deposited On:18 Oct 2018 09:53
Last Modified:24 Sep 2019 23:42
Publisher:Elsevier
ISSN:0007-0912
OA Status:Green
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1093/bja/59.8.1044
Related URLs:https://www.swissbib.ch/Search/Results?lookfor=nationallicenceoxford101093bja5981044 (Library Catalogue)

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