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Effects on ionized calcium of a correction of acidosis with alkalinizing agents


Schaer, H (1976). Effects on ionized calcium of a correction of acidosis with alkalinizing agents. British Journal of Anaesthesia, 48(4):327-332.

Abstract

SUMMARY The effects on the ionized calcium concentration of a correction of various forms of acidosis with sodium bicarbonate or (tris-hydroxymethyl)aminomethane (THAM) were investigated in vitro in human plasma. Calculation of least square regression equations of ionized calcium (m mol) on pH yielded the following regression coefficients: hydrochloric acidosis: —0.65±0.06; lactic acidosis: —0.27±0.05; hydrochloric acidosis corrected with sodium bicarbonate: —0.65±0.02; lactic acidosis corrected with sodium bicarbonate: —0.51±0.03. The results indicate that after correction of lactic acidosis the ionized calcium concentration will be below the control values while pH is restored to the normal range. This effect is even more pronounced when THAM is used. The findings point to the need for calcium administration in cardiac resuscitation

Abstract

SUMMARY The effects on the ionized calcium concentration of a correction of various forms of acidosis with sodium bicarbonate or (tris-hydroxymethyl)aminomethane (THAM) were investigated in vitro in human plasma. Calculation of least square regression equations of ionized calcium (m mol) on pH yielded the following regression coefficients: hydrochloric acidosis: —0.65±0.06; lactic acidosis: —0.27±0.05; hydrochloric acidosis corrected with sodium bicarbonate: —0.65±0.02; lactic acidosis corrected with sodium bicarbonate: —0.51±0.03. The results indicate that after correction of lactic acidosis the ionized calcium concentration will be below the control values while pH is restored to the normal range. This effect is even more pronounced when THAM is used. The findings point to the need for calcium administration in cardiac resuscitation

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Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Anesthesiology and Pain Medicine
Language:English
Date:1 April 1976
Deposited On:01 Nov 2018 13:40
Last Modified:31 Jul 2020 02:22
Publisher:Elsevier
ISSN:0007-0912
OA Status:Green
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1093/bja/48.4.327
Related URLs:https://www.swissbib.ch/Search/Results?lookfor=nationallicenceoxford101093bja484327 (Library Catalogue)

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