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Absorption and bioavailability of nebulized morphine


Chrubasik, J; Wüst, H; Friedrich, G; Geller, E (1988). Absorption and bioavailability of nebulized morphine. British Journal of Anaesthesia, 61(2):228-230.

Abstract

During anaesthesia seven patients received a bolus of morphine 10 mg injected into the nebulization reservoir placed between the tracheal tube and the anaesthetic circle (lH). Five days after operation the same seven patients received morphine 10 mg i.m. On both occasions, venous blood samples were taken before and every 15 min after administration over 4.5 h for measurement of free morphine immunoreactivity by radioimmunoassay. There was marked individual variation in the serum morphine concentrations produced following each route of administration. The maximum serum morphine concentration following inhaled morphine was approx. six times lower than that after morphine i.m. and the time of occurrence differed significantly (P < 0.001). The individual relative bioavailabilities of inhaled morphine varied from 9% to 35%, with a mean of 17%

Abstract

During anaesthesia seven patients received a bolus of morphine 10 mg injected into the nebulization reservoir placed between the tracheal tube and the anaesthetic circle (lH). Five days after operation the same seven patients received morphine 10 mg i.m. On both occasions, venous blood samples were taken before and every 15 min after administration over 4.5 h for measurement of free morphine immunoreactivity by radioimmunoassay. There was marked individual variation in the serum morphine concentrations produced following each route of administration. The maximum serum morphine concentration following inhaled morphine was approx. six times lower than that after morphine i.m. and the time of occurrence differed significantly (P < 0.001). The individual relative bioavailabilities of inhaled morphine varied from 9% to 35%, with a mean of 17%

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:610 Medicine & health
Uncontrolled Keywords:Anesthesiology and Pain Medicine
Language:English
Date:1 August 1988
Deposited On:18 Oct 2018 09:37
Last Modified:24 Sep 2019 23:42
Publisher:Elsevier
ISSN:0007-0912
OA Status:Green
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1093/bja/61.2.228
Related URLs:https://www.swissbib.ch/Search/Results?lookfor=nationallicenceoxford101093bja612228 (Library Catalogue)

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