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Age-Related Activity Changes in Arginine Phosphokinase in the House Fly, Musca Domestica L


Baker III, G T (1975). Age-Related Activity Changes in Arginine Phosphokinase in the House Fly, Musca Domestica L. Journal of Gerontology, 30(2):163-169.

Abstract

The activity of ATP:L-arginine phosphotransferase (E.C.2.7.3.3.). Was shown to exhibit agedependent changes in both male and female house fly. Enzyme activity demonstrated more marked changes in the male than in the female, increasing 44-fold from emergence to a peak at 2 days of age and thereafter declining, at first sharply then gradually to a value at 14 days of age, representing a third of the activity found at the peak. Activity in the female fly also showed a peak at 2 days of age, which thereafter declined, although more gradually than was observed in the male. Activity changes expressed on a per fly or wet weight basis were nearly identical. Agerelated activity changes on a milligram protein basis demonstrated similar increases; however, the percentage decrease from the 2-day peaks were less striking, although highly significant. No kinetic or physical changes in the enzyme were detected, nor could any soluble inhibitors or activators of the enzyme be identified. The changes in arginine phosphokinase activity fall into a sequential pattern of enzyme changes, reflecting an apparently ordered mechanism underlying a decline in flight ability in this species

Abstract

The activity of ATP:L-arginine phosphotransferase (E.C.2.7.3.3.). Was shown to exhibit agedependent changes in both male and female house fly. Enzyme activity demonstrated more marked changes in the male than in the female, increasing 44-fold from emergence to a peak at 2 days of age and thereafter declining, at first sharply then gradually to a value at 14 days of age, representing a third of the activity found at the peak. Activity in the female fly also showed a peak at 2 days of age, which thereafter declined, although more gradually than was observed in the male. Activity changes expressed on a per fly or wet weight basis were nearly identical. Agerelated activity changes on a milligram protein basis demonstrated similar increases; however, the percentage decrease from the 2-day peaks were less striking, although highly significant. No kinetic or physical changes in the enzyme were detected, nor could any soluble inhibitors or activators of the enzyme be identified. The changes in arginine phosphokinase activity fall into a sequential pattern of enzyme changes, reflecting an apparently ordered mechanism underlying a decline in flight ability in this species

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:Unspecified
Scopus Subject Areas:Life Sciences > Aging
Language:English
Date:1 March 1975
Deposited On:18 Oct 2018 13:27
Last Modified:12 Jul 2021 20:22
Publisher:Oxford University Press
ISSN:0022-1422
OA Status:Green
Publisher DOI:https://doi.org/10.1093/geronj/30.2.163

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