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Effect of a prebiotic mixture on intestinal comfort and general wellbeing in health


Goetze, Oliver; Fruehauf, Heiko; Pohl, Daniel; Giarrè, Marianna; Rochat, Florence; Ornstein, Kurt; Menne, Dieter; Fried, Michael; Thumshirn, Miriam (2008). Effect of a prebiotic mixture on intestinal comfort and general wellbeing in health. The British Journal of Nutrition, 100(5):1077-1085.

Abstract

Specific carbohydrates, i.e. prebiotics such as fructo-oligosaccharide (FOS), are not digested in the small intestine but fermented in the colon. Besides beneficial health effects of an enhanced bifidobacteria population, intestinal gas production resulting from fermentation can induce abdominal symptoms. Partial replacement with slowly fermented acacia gum may attenuate side effects. The aim was to compare the effects of FOS with those of a prebiotic mixture (50% FOS and 50% acacia gum; BLEND) and a rapidly absorbed carbohydrate (maltodextrin) on general intestinal wellbeing, abdominal comfort and anorectal sensory function. Twenty volunteers (eight male and twelve female; age 20-37 years) completed this double-blind, randomised study with two cycles of a 2-week run-in phase (10g maltodextrin) followed by 5 weeks of 10g FOS or BLEND once daily, separated by a 4-week wash-out interval. Abdominal symptoms and general wellbeing were documented by telephone interview or Internet twice weekly. Rectal sensations were assessed by a visual analogue scale during a rectal barostat test after FOS and BLEND treatment. Both FOS and BLEND induced more side effects than maltodextrin. Belching was more pronounced under FOS compared with BLEND (P=0·09 for females; P=0·01 for males), and for self-reported general wellbeing strong sex differences were reported (P=0·002). Urgency scores during rectal barostat were higher with FOS than BLEND (P=0·01). Faced with a growing range of supplemented food products, consumers may benefit from prebiotic mixtures which cause fewer abdominal side effects. Sex differences must be taken in consideration when food supplements are used

Abstract

Specific carbohydrates, i.e. prebiotics such as fructo-oligosaccharide (FOS), are not digested in the small intestine but fermented in the colon. Besides beneficial health effects of an enhanced bifidobacteria population, intestinal gas production resulting from fermentation can induce abdominal symptoms. Partial replacement with slowly fermented acacia gum may attenuate side effects. The aim was to compare the effects of FOS with those of a prebiotic mixture (50% FOS and 50% acacia gum; BLEND) and a rapidly absorbed carbohydrate (maltodextrin) on general intestinal wellbeing, abdominal comfort and anorectal sensory function. Twenty volunteers (eight male and twelve female; age 20-37 years) completed this double-blind, randomised study with two cycles of a 2-week run-in phase (10g maltodextrin) followed by 5 weeks of 10g FOS or BLEND once daily, separated by a 4-week wash-out interval. Abdominal symptoms and general wellbeing were documented by telephone interview or Internet twice weekly. Rectal sensations were assessed by a visual analogue scale during a rectal barostat test after FOS and BLEND treatment. Both FOS and BLEND induced more side effects than maltodextrin. Belching was more pronounced under FOS compared with BLEND (P=0·09 for females; P=0·01 for males), and for self-reported general wellbeing strong sex differences were reported (P=0·002). Urgency scores during rectal barostat were higher with FOS than BLEND (P=0·01). Faced with a growing range of supplemented food products, consumers may benefit from prebiotic mixtures which cause fewer abdominal side effects. Sex differences must be taken in consideration when food supplements are used

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Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:610 Medicine & health
570 Life sciences; biology
630 Agriculture
Language:English
Date:1 November 2008
Deposited On:13 Nov 2018 16:10
Last Modified:24 Sep 2019 23:42
Publisher:Cambridge University Press
ISSN:0007-1145
OA Status:Green
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1017/s0007114508960918
Related URLs:https://www.swissbib.ch/Search/Results?lookfor=nationallicencecambridge101017S0007114508960918 (Library Catalogue)
PubMed ID:18377682

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