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Sex-specific meiotic recombination in the Prader--Willi/Angelman syndrome imprinted region


Robinson, W P; Lalande, M (1995). Sex-specific meiotic recombination in the Prader--Willi/Angelman syndrome imprinted region. Human Molecular Genetics, 4(5):801-806.

Abstract

Meiotic recombination is a specifically timed and regulated process which does not occur randomly throughout the genome, but tends to be clustered in ‘hotspots'. There is extensive evidence that recombinatlon rate is influenced by chromatin conformation and that events are primarily initiated at gene promoter regions. In an effort to determine the pattern of chromatin condensation and recombinatlon at meiosis in an imprinted region, fine scale genetic mapping in the approximately 4 Mb Prader-Willi/Angelman syndrome deletion region was undertaken. The results Indicate that the male-female recombinatlon ratio can vary significantly over short regions. A male recombinatlon hotspot is localized to between the 3' end of GABRA5 and Dl 5S1 56, which Is adjacent to but outside the putative AS/PWS imprinted regions. In addition, a region of relatively high recombination In females is observed between Dl 5S1 28 and D15S97, which spans a domain of paternal allele-specific transcription implicated in the Prader-Willi syndrome. It is inferred that the Inactivation and relative condensation of this latter region on the maternal chromosome occurs as a post-meiotic modification

Abstract

Meiotic recombination is a specifically timed and regulated process which does not occur randomly throughout the genome, but tends to be clustered in ‘hotspots'. There is extensive evidence that recombinatlon rate is influenced by chromatin conformation and that events are primarily initiated at gene promoter regions. In an effort to determine the pattern of chromatin condensation and recombinatlon at meiosis in an imprinted region, fine scale genetic mapping in the approximately 4 Mb Prader-Willi/Angelman syndrome deletion region was undertaken. The results Indicate that the male-female recombinatlon ratio can vary significantly over short regions. A male recombinatlon hotspot is localized to between the 3' end of GABRA5 and Dl 5S1 56, which Is adjacent to but outside the putative AS/PWS imprinted regions. In addition, a region of relatively high recombination In females is observed between Dl 5S1 28 and D15S97, which spans a domain of paternal allele-specific transcription implicated in the Prader-Willi syndrome. It is inferred that the Inactivation and relative condensation of this latter region on the maternal chromosome occurs as a post-meiotic modification

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Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Scopus Subject Areas:Life Sciences > Molecular Biology
Life Sciences > Genetics
Health Sciences > Genetics (clinical)
Language:English
Date:1 May 1995
Deposited On:12 Oct 2018 08:18
Last Modified:31 Jul 2020 02:25
Publisher:Oxford University Press
ISSN:0964-6906
OA Status:Green
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1093/hmg/4.5.801
Related URLs:https://www.swissbib.ch/Search/Results?lookfor=nationallicenceoxford101093hmg45801 (Library Catalogue)

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