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Diverse pathogenicity ofBurkholderia cepaciacomplex strains in theCaenorhabditis eleganshost model


Cardona, Silvia T; Wopperer, Julia; Eberl, Leo; Valvano, Miguel A (2005). Diverse pathogenicity ofBurkholderia cepaciacomplex strains in theCaenorhabditis eleganshost model. FEMS Microbiology Letters, 250(1):97-104.

Abstract

A fast screening method was developed to assess the pathogenicity of a diverse collection of environmental and clinical Burkholderia cepacia complex isolates in the nematode Caenorhabditis elegans. The method was validated by comparison with the standard slow-killing assay. We observed that the pathogenicity of B. cepacia complex isolates in C. elegans was strain-dependent but species-independent. The wide range of observed pathogenic phenotypes agrees with the high degree of phenotypic variation among species of the B. cepacia complex and suggests that the taxonomic classification of a given strain within the complex cannot predict pathogenicity

Abstract

A fast screening method was developed to assess the pathogenicity of a diverse collection of environmental and clinical Burkholderia cepacia complex isolates in the nematode Caenorhabditis elegans. The method was validated by comparison with the standard slow-killing assay. We observed that the pathogenicity of B. cepacia complex isolates in C. elegans was strain-dependent but species-independent. The wide range of observed pathogenic phenotypes agrees with the high degree of phenotypic variation among species of the B. cepacia complex and suggests that the taxonomic classification of a given strain within the complex cannot predict pathogenicity

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Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Scopus Subject Areas:Life Sciences > Microbiology
Life Sciences > Molecular Biology
Life Sciences > Genetics
Language:English
Date:1 September 2005
Deposited On:23 Oct 2018 13:05
Last Modified:31 Jul 2020 02:26
Publisher:Oxford University Press
ISSN:0378-1097
OA Status:Hybrid
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1016/j.femsle.2005.06.050
Related URLs:https://www.swissbib.ch/Search/Results?lookfor=nationallicenceoxford101016jfemsle200506050 (Library Catalogue)

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