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Impact ofsarandagron methicillin resistance inStaphylococcus aureus


Durán, S P; Kayser, F H; Berger-Bächi, B (1996). Impact ofsarandagron methicillin resistance inStaphylococcus aureus. FEMS Microbiology Letters, 141(2-3):255-260.

Abstract

The global regulators agr and sar control expression of cell wall and extracellular proteins. Inactivation of either sar and/or agr in a typical heterogeneously methicillin-resistant Staphylococcus aureus resulted in a small but reproducible decrease in the number of cells in the subpopulation expressing high methicillin resistance. The amount of low affinity penicillin-binding protein PBP2′, the prerequisite for methicillin resistance, was apparently not affected, however, a reduction in PBP1 and PBP3 production was observed, suggesting that these resident PBPs of the cells might be involved somehow together with PBP2′ in high level methicillin resistance

Abstract

The global regulators agr and sar control expression of cell wall and extracellular proteins. Inactivation of either sar and/or agr in a typical heterogeneously methicillin-resistant Staphylococcus aureus resulted in a small but reproducible decrease in the number of cells in the subpopulation expressing high methicillin resistance. The amount of low affinity penicillin-binding protein PBP2′, the prerequisite for methicillin resistance, was apparently not affected, however, a reduction in PBP1 and PBP3 production was observed, suggesting that these resident PBPs of the cells might be involved somehow together with PBP2′ in high level methicillin resistance

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:1 August 1996
Deposited On:12 Oct 2018 06:38
Last Modified:12 Oct 2018 06:38
Publisher:Oxford University Press
ISSN:0378-1097
OA Status:Green
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1111/j.1574-6968.1996.tb08394.x
Related URLs:https://www.swissbib.ch/Search/Results?lookfor=nationallicenceoxford101111j157469681996tb08394x (Library Catalogue)

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