Header

UZH-Logo

Maintenance Infos

Genotoxicity testing of antiparasitic nitrofurans in the Drosophila wing somatic mutation and recombination test


Moraga, Angeles Alonso; Graf, Ulrich (1989). Genotoxicity testing of antiparasitic nitrofurans in the Drosophila wing somatic mutation and recombination test. Mutagenesis, 4(2):105-110.

Abstract

Nifurtimox and eight structurally related 5-nitrofuran compounds active against Trypanosoma cruzi were tested for genotoxicity in the wing somatic mutation and recombination test in Drosophila melanogaster. Nifurtimox, compound ada and compound 1B were clearly mutagenic and recombinogenic whereas the remaining six compounds were negative. In contrast to the situation in bacterial mutagenicity tests, nitroreductase activity is probably not decisive for the genotoxicity of these compounds in Drosophila. The three non-genotoxic nitrofurans with high antiparasitic activity are promising candidates for the replacement of nifurtimox. However, these compounds require further genotoxicity testing in eukaryotic assay systems for a final evaluation

Abstract

Nifurtimox and eight structurally related 5-nitrofuran compounds active against Trypanosoma cruzi were tested for genotoxicity in the wing somatic mutation and recombination test in Drosophila melanogaster. Nifurtimox, compound ada and compound 1B were clearly mutagenic and recombinogenic whereas the remaining six compounds were negative. In contrast to the situation in bacterial mutagenicity tests, nitroreductase activity is probably not decisive for the genotoxicity of these compounds in Drosophila. The three non-genotoxic nitrofurans with high antiparasitic activity are promising candidates for the replacement of nifurtimox. However, these compounds require further genotoxicity testing in eukaryotic assay systems for a final evaluation

Statistics

Citations

Dimensions.ai Metrics
48 citations in Web of Science®
61 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

27 downloads since deposited on 17 Oct 2018
13 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:Unspecified
Scopus Subject Areas:Life Sciences > Genetics
Life Sciences > Toxicology
Health Sciences > Genetics (clinical)
Physical Sciences > Health, Toxicology and Mutagenesis
Language:English
Date:1 January 1989
Deposited On:17 Oct 2018 14:54
Last Modified:15 Apr 2021 14:51
Publisher:Oxford University Press
ISSN:0267-8357
OA Status:Green
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1093/mutage/4.2.105

Download

Green Open Access

Download PDF  'Genotoxicity testing of antiparasitic nitrofurans in the Drosophila wing somatic mutation and recombination test'.
Preview
Content: Published Version
Language: English
Filetype: PDF (Nationallizenz 142-005)
Size: 581kB
View at publisher