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Airborne exposure to polycyclic aromatic hydrocarbons (pahs) and urinary excretion of 1-hydroxypyrene of carbon anode plant workers


Petry, Thomas; Schmidt, Peter; Schlatter, Christian (1996). Airborne exposure to polycyclic aromatic hydrocarbons (pahs) and urinary excretion of 1-hydroxypyrene of carbon anode plant workers. Annals of Occupational Hygiene, 40(3):345-357.

Abstract

Workers in plants producing carbon anodes for aluminium electrolysis are exposed to PAHs containing coal tar pitch volatiles, pitch and coke. The aim of this study was to evaluate the suitability of urinary 1-hydroxypyrene to characterize respiratory exposure to PAH, which is most relevant for assessing individual health risks. Six workers in a carbon anode plant volunteered to take part in a personal air sampling and a biological monitoring programme lasting five consecutive 8-h shifts to determine occupational exposure to airborne PAHs and urinary excretion of l-hydroxypyrene. Exposure to total PAH for all worksites varied from 3.99 to 120.6 μg PAH m−3 and for benzo(a)pyrene (BaP) from 0.17 to 4.88 μg BaP m−3. The concentration of 1-hydroxypyrene in post- and pre-shift urine samples was in the range (0.5-61.8 μmol 1-OHP per mol creatinine) and depended on the worksite. The Spearman rank correlation test showed a low but significant (P<0.05) correlation of urinary 1-hydroxypyrene in the post- and pre-shift samples with respiratory pyrene exposure. The quantitative aspects of biological monitoring for the evaluation of respiratory PAH exposure were tested with a pharmacokinetic model. On the basis of individual pyrene exposure, excretion of urinary 1- hydroxypyrene during the working week was calculated for each worker. The results presented in this investigation indicate that biological monitoring of the pyrene metabolite 1-hydroxypyrene is a useful indicator of a general PAll exposure, but cannot replace personal air sampling for assessing the lung cancer risk of individuals. Copyright © 1996 BOHS. Published by Elsevier Science Ltd

Abstract

Workers in plants producing carbon anodes for aluminium electrolysis are exposed to PAHs containing coal tar pitch volatiles, pitch and coke. The aim of this study was to evaluate the suitability of urinary 1-hydroxypyrene to characterize respiratory exposure to PAH, which is most relevant for assessing individual health risks. Six workers in a carbon anode plant volunteered to take part in a personal air sampling and a biological monitoring programme lasting five consecutive 8-h shifts to determine occupational exposure to airborne PAHs and urinary excretion of l-hydroxypyrene. Exposure to total PAH for all worksites varied from 3.99 to 120.6 μg PAH m−3 and for benzo(a)pyrene (BaP) from 0.17 to 4.88 μg BaP m−3. The concentration of 1-hydroxypyrene in post- and pre-shift urine samples was in the range (0.5-61.8 μmol 1-OHP per mol creatinine) and depended on the worksite. The Spearman rank correlation test showed a low but significant (P<0.05) correlation of urinary 1-hydroxypyrene in the post- and pre-shift samples with respiratory pyrene exposure. The quantitative aspects of biological monitoring for the evaluation of respiratory PAH exposure were tested with a pharmacokinetic model. On the basis of individual pyrene exposure, excretion of urinary 1- hydroxypyrene during the working week was calculated for each worker. The results presented in this investigation indicate that biological monitoring of the pyrene metabolite 1-hydroxypyrene is a useful indicator of a general PAll exposure, but cannot replace personal air sampling for assessing the lung cancer risk of individuals. Copyright © 1996 BOHS. Published by Elsevier Science Ltd

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:340 Law
610 Medicine & health
Language:English
Date:1 June 1996
Deposited On:12 Oct 2018 06:48
Last Modified:24 Nov 2018 03:05
Publisher:Oxford University Press
ISSN:0003-4878
OA Status:Green
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1093/annhyg/40.3.345
Related URLs:https://www.swissbib.ch/Search/Results?lookfor=nationallicenceoxford101093annhyg403345 (Library Catalogue)

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