Header

UZH-Logo

Maintenance Infos

Taurolidine: a novel anti-neoplastic agent induces apoptosis of osteosarcoma cell lines


Walters, Denise K; Muff, Roman; Langsam, Bettina; Gruber, Philipp; Born, Walter; Fuchs, Bruno (2007). Taurolidine: a novel anti-neoplastic agent induces apoptosis of osteosarcoma cell lines. Investigational New Drugs, 25(4):305-312.

Abstract

Taurolidine, the active agent of Taurolin®, is a broad spectrum anti-biotic that has been used for over 15years for the treatment of severe surgical infections. Recently, taurolidine has been shown to possess anti-neoplastic properties in vitro and in vivo against a variety of cancers including ovarian, colon and prostate. In this study we assessed the cytotoxic activity of taurolidine against human osteosarcoma (OS) cell lines and normal human bone cells. Treatment with taurolidine inhibited the growth of all ten osteosarcoma cell lines tested and taurolidine was equally potent against cell lines with and without distinct genetic defects (i.e. p53, Rb). Moreover, taurolidine-induced growth inhibition was found to be associated with a dose dependent increase in the number of apoptotic cells and apoptosis was shown to be caspase-dependent. Taurolidine treatment was also found to inhibit adhesion of OS cell lines. Compared to OS cell lines, normal bone cells in primary culture were found to be less sensitive to the cytotoxic and anti-adhesive effects of taurolidine. These data indicate that taurolidine possesses potent anti-neoplastic activity against osteosarcoma cell lines and may have potential as a novel OS chemotherapeutic agent

Abstract

Taurolidine, the active agent of Taurolin®, is a broad spectrum anti-biotic that has been used for over 15years for the treatment of severe surgical infections. Recently, taurolidine has been shown to possess anti-neoplastic properties in vitro and in vivo against a variety of cancers including ovarian, colon and prostate. In this study we assessed the cytotoxic activity of taurolidine against human osteosarcoma (OS) cell lines and normal human bone cells. Treatment with taurolidine inhibited the growth of all ten osteosarcoma cell lines tested and taurolidine was equally potent against cell lines with and without distinct genetic defects (i.e. p53, Rb). Moreover, taurolidine-induced growth inhibition was found to be associated with a dose dependent increase in the number of apoptotic cells and apoptosis was shown to be caspase-dependent. Taurolidine treatment was also found to inhibit adhesion of OS cell lines. Compared to OS cell lines, normal bone cells in primary culture were found to be less sensitive to the cytotoxic and anti-adhesive effects of taurolidine. These data indicate that taurolidine possesses potent anti-neoplastic activity against osteosarcoma cell lines and may have potential as a novel OS chemotherapeutic agent

Statistics

Citations

Dimensions.ai Metrics
23 citations in Web of Science®
24 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

11 downloads since deposited on 27 Nov 2018
11 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:14 June 2007
Deposited On:27 Nov 2018 16:20
Last Modified:28 Nov 2018 01:40
Publisher:Springer
ISSN:0167-6997
OA Status:Green
Publisher DOI:https://doi.org/10.1007/s10637-007-9052-9
Related URLs:https://www.swissbib.ch/Search/Results?lookfor=nationallicencespringer101007s1063700790529 (Library Catalogue)
PubMed ID:17458504

Download

Download PDF  'Taurolidine: a novel anti-neoplastic agent induces apoptosis of osteosarcoma cell lines'.
Preview
Content: Published Version
Language: English
Filetype: PDF (Nationallizenz 142-005)
Size: 311kB
View at publisher