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Hyperuricemia and gout following pediatric renal transplantation


Spartà, Giuseppina; Kemper, Markus J; Neuhaus, Thomas J (2006). Hyperuricemia and gout following pediatric renal transplantation. Pediatric Nephrology, 21(12):1884-1888.

Abstract

Hyperuricemia and gout are common complications in adult renal transplant recipients. In pediatric recipients, however, hyperuricemia seems to be rare, but data are scarce. Thirty-two children (21 males, 11 females) were investigated for a median time of 4.8years (range: 0.4-11.2years) following renal transplantation. The median age of this pediatric study group was 13.9years (range: 5.7-20.3years), and the calculated glomerular filtration rate (GFR) was 61ml/min per 1.73m2 (range:12-88ml/min per 1.73m2). All patients were given calcineurin inhibitors, with 22 and ten children receiving cyclosporine A (CSA) and tacrolimus (TAC), respectively. The median plasma uric acid was 385μmol/l (range: 62-929μmol/l); 15 children (47%) were above the age-related normal range. Only one patient experienced gouty arthritis. There was a significant correlation between plasma uric acid concentration and both time span after transplantation and plasma creatinine, and an inverse correlation to GFR (p<0.05). No significant correlation was found between plasma uric acid and body mass index (BMI). Plasma uric acid concentrations were neither different among CSA- and TAC-treated children, nor did they correlate with drug exposure or blood trough levels of CSA or TAC. Plasma uric acid concentration was not different when compared to children with chronic renal failure (CRF) of a similar degree in native kidneys. We conclude that hyperuricemia is common among pediatric renal transplant recipients and rather a consequence of chronic renal transplant dysfunction than the use of calcineurin inhibitors. Gout, however, is rare

Abstract

Hyperuricemia and gout are common complications in adult renal transplant recipients. In pediatric recipients, however, hyperuricemia seems to be rare, but data are scarce. Thirty-two children (21 males, 11 females) were investigated for a median time of 4.8years (range: 0.4-11.2years) following renal transplantation. The median age of this pediatric study group was 13.9years (range: 5.7-20.3years), and the calculated glomerular filtration rate (GFR) was 61ml/min per 1.73m2 (range:12-88ml/min per 1.73m2). All patients were given calcineurin inhibitors, with 22 and ten children receiving cyclosporine A (CSA) and tacrolimus (TAC), respectively. The median plasma uric acid was 385μmol/l (range: 62-929μmol/l); 15 children (47%) were above the age-related normal range. Only one patient experienced gouty arthritis. There was a significant correlation between plasma uric acid concentration and both time span after transplantation and plasma creatinine, and an inverse correlation to GFR (p<0.05). No significant correlation was found between plasma uric acid and body mass index (BMI). Plasma uric acid concentrations were neither different among CSA- and TAC-treated children, nor did they correlate with drug exposure or blood trough levels of CSA or TAC. Plasma uric acid concentration was not different when compared to children with chronic renal failure (CRF) of a similar degree in native kidneys. We conclude that hyperuricemia is common among pediatric renal transplant recipients and rather a consequence of chronic renal transplant dysfunction than the use of calcineurin inhibitors. Gout, however, is rare

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Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:8 November 2006
Deposited On:02 Nov 2018 07:52
Last Modified:24 Nov 2018 03:06
Publisher:Springer
ISSN:0931-041X
OA Status:Green
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1007/s00467-006-0257-5
Related URLs:https://www.swissbib.ch/Search/Results?lookfor=nationallicencespringer101007s0046700602575 (Library Catalogue)

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