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Genome sequence of the temperate bacteriophage PH10 from Streptococcus oralis


van der Ploeg, Jan R (2010). Genome sequence of the temperate bacteriophage PH10 from Streptococcus oralis. Virus Genes, 41(3):450-458.

Abstract

Exponential growing cultures of Streptococcus oralis strain OMZ 1038, isolated from human supragingival dental plaque, were found to release a bacteriophage (designated PH10) upon treatment with mitomycin C. The complete genome sequence of phage PH10 was determined. The genome was 31276bp in size and contained 54 open reading frames. The module encoding structural proteins was highly similar to that of Streptococcus pneumoniae prophage PhiSpn_3. The most abundant phage structural protein was encoded by ORF35 and was likely processed by proteolytic cleavage. The putative endolysin from PH10, which contained a muramidase domain and a choline-binding domain, was purified and shown to have lytic activity with S. oralis, S. pneumoniae and Streptococcus mitis, but not with other streptococcal species

Abstract

Exponential growing cultures of Streptococcus oralis strain OMZ 1038, isolated from human supragingival dental plaque, were found to release a bacteriophage (designated PH10) upon treatment with mitomycin C. The complete genome sequence of phage PH10 was determined. The genome was 31276bp in size and contained 54 open reading frames. The module encoding structural proteins was highly similar to that of Streptococcus pneumoniae prophage PhiSpn_3. The most abundant phage structural protein was encoded by ORF35 and was likely processed by proteolytic cleavage. The putative endolysin from PH10, which contained a muramidase domain and a choline-binding domain, was purified and shown to have lytic activity with S. oralis, S. pneumoniae and Streptococcus mitis, but not with other streptococcal species

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Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:Unspecified
Language:English
Date:1 December 2010
Deposited On:28 Nov 2018 17:59
Last Modified:24 Sep 2019 23:44
Publisher:Springer
ISSN:0920-8569
OA Status:Green
Publisher DOI:https://doi.org/10.1007/s11262-010-0525-0
Related URLs:https://www.swissbib.ch/Search/Results?lookfor=nationallicencespringer101007s1126201005250 (Library Catalogue)
PubMed ID:20803062

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