Header

UZH-Logo

Maintenance Infos

Psychische und familiäre Risiken für Kinder von Frauen mit Epilepsie?


Titze, Karl; Helge, Hans; Koch, Sabine; Lehmkuhl, Ulrike; Rauh, Hellgard; Steinhausen, Hans-Christoph (2007). Psychische und familiäre Risiken für Kinder von Frauen mit Epilepsie? Zeitschrift für Epileptologie, 20(1):34-40.

Abstract

This study investigates teratogenic effects of antiepileptic drugs (AED) by tracing from birth to adolescence 67 children born to epileptic women and a matched control sample of 49 children. We assessed the intellectual performance (Wechsler-Intelligence Tests) at adolescence as well as the prevalence of psycho-behavioral problems and the relationship to their parents. Adolescents who had been exposed to only one kind of drug during gestation (monotherapy), achieved moderately lower IQ's than those of the control group (-6 IQ scores). However, the effect was salient in polydrug-exposed offspring (-12 IQ scores). Generalized (major) maternal seizures during pregnancy did not add to this effect. The families' psychosocial ecology affected risk and control participants differentially: The intellectual development of adolescents with prenatal risks was significantly more vulnerable to adverse environmental circumstances than was that of controls. With regard to psychological stress the affected children unexpectedly reported significantly less psychological stress than the controls even though they had to assist their mothers more frequently and although they reported receiving little support from them

Abstract

This study investigates teratogenic effects of antiepileptic drugs (AED) by tracing from birth to adolescence 67 children born to epileptic women and a matched control sample of 49 children. We assessed the intellectual performance (Wechsler-Intelligence Tests) at adolescence as well as the prevalence of psycho-behavioral problems and the relationship to their parents. Adolescents who had been exposed to only one kind of drug during gestation (monotherapy), achieved moderately lower IQ's than those of the control group (-6 IQ scores). However, the effect was salient in polydrug-exposed offspring (-12 IQ scores). Generalized (major) maternal seizures during pregnancy did not add to this effect. The families' psychosocial ecology affected risk and control participants differentially: The intellectual development of adolescents with prenatal risks was significantly more vulnerable to adverse environmental circumstances than was that of controls. With regard to psychological stress the affected children unexpectedly reported significantly less psychological stress than the controls even though they had to assist their mothers more frequently and although they reported receiving little support from them

Statistics

Citations

Dimensions.ai Metrics

Altmetrics

Downloads

21 downloads since deposited on 29 Nov 2018
9 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Pediatrics, Perinatology and Child Health
Health Sciences > Neurology (clinical)
Language:German
Date:1 February 2007
Deposited On:29 Nov 2018 16:06
Last Modified:31 Jul 2020 02:35
Publisher:Springer
ISSN:1610-0646
OA Status:Green
Publisher DOI:https://doi.org/10.1007/s10309-006-0225-x
Related URLs:https://www.swissbib.ch/Search/Results?lookfor=nationallicencespringer101007s103090060225x (Library Catalogue)

Download

Green Open Access

Download PDF  'Psychische und familiäre Risiken für Kinder von Frauen mit Epilepsie?'.
Preview
Content: Published Version
Language: German
Filetype: PDF (Nationallizenz 142-005)
Size: 309kB
View at publisher