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Disseminated invasive aspergillosis with cerebral involvement successfully treated with caspofungin and voriconazole


Gubler, C; Wildi, S M; Imhof, A; Schneemann, M; Müllhaupt, B (2007). Disseminated invasive aspergillosis with cerebral involvement successfully treated with caspofungin and voriconazole. Infection, 35(5):364-366.

Abstract

We describe a case of cerebral aspergillosis which was successfully treated with a combination of caspofungin and voriconazole. The patient remains in remission 18 months after stopping antifungal treatment. We discuss primary and salvage therapy of invasive aspergillosis with focus on cerebral involvement. Since historical data showed a fatal outcome in most cases, amphotericin B does not cross the blood brain barrier while voriconazole does, we chose a combination of voriconazole plus caspofungin as primary therapy

Abstract

We describe a case of cerebral aspergillosis which was successfully treated with a combination of caspofungin and voriconazole. The patient remains in remission 18 months after stopping antifungal treatment. We discuss primary and salvage therapy of invasive aspergillosis with focus on cerebral involvement. Since historical data showed a fatal outcome in most cases, amphotericin B does not cross the blood brain barrier while voriconazole does, we chose a combination of voriconazole plus caspofungin as primary therapy

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Microbiology (medical)
Health Sciences > Infectious Diseases
Language:English
Date:1 October 2007
Deposited On:03 Dec 2018 16:09
Last Modified:27 Feb 2024 04:41
Publisher:Springer
ISSN:0300-8126
OA Status:Green
Publisher DOI:https://doi.org/10.1007/s15010-007-6165-1
PubMed ID:17721739
  • Content: Published Version
  • Language: English
  • Description: Nationallizenz 142-005