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GABA(A) receptor diversity and pharmacology


Möhler, H (2006). GABA(A) receptor diversity and pharmacology. Cell and Tissue Research, 326(2):505-516.

Abstract

Because of its control of spike-timing and oscillatory network activity, γ-aminobutyric acid (GABA)-ergic inhibition is a key element in the central regulation of somatic and mental functions. The recognition of GABAA receptor diversity has provided molecular tags for the analysis of distinct neuronal networks in the control of specific pharmacological and physiological brain functions. Neurons expressing α1GABAA receptors have been found to mediate sedation, whereas those expressing α2GABAA receptors mediate anxiolysis. Furthermore, associative temporal and spatial memory can be regulated by modulating the activity of hippocampal pyramidal cells via extrasynaptic α5GABAA receptors. In addition, neurons expressing α3GABAA receptors are instrumental in the processing of sensory motor information related to a schizophrenia endophenotype. Finally, during the postnatal development of the brain, the maturation of GABAergic interneurons seems to provide the trigger for the experience-dependent plasticity of neurons in the visual cortex, with α1GABAA receptors setting the time of onset of a critical period of plasticity. Thus, particular neuronal networks defined by respective GABAA receptor subtypes can now be linked to the regulation of various clearly defined behavioural patterns. These achievements are of obvious relevance for the pharmacotherapy of certain brain disorders, in particular sleep dysfunctions, anxiety disorders, schizophrenia and diseases associated with memory deficits

Abstract

Because of its control of spike-timing and oscillatory network activity, γ-aminobutyric acid (GABA)-ergic inhibition is a key element in the central regulation of somatic and mental functions. The recognition of GABAA receptor diversity has provided molecular tags for the analysis of distinct neuronal networks in the control of specific pharmacological and physiological brain functions. Neurons expressing α1GABAA receptors have been found to mediate sedation, whereas those expressing α2GABAA receptors mediate anxiolysis. Furthermore, associative temporal and spatial memory can be regulated by modulating the activity of hippocampal pyramidal cells via extrasynaptic α5GABAA receptors. In addition, neurons expressing α3GABAA receptors are instrumental in the processing of sensory motor information related to a schizophrenia endophenotype. Finally, during the postnatal development of the brain, the maturation of GABAergic interneurons seems to provide the trigger for the experience-dependent plasticity of neurons in the visual cortex, with α1GABAA receptors setting the time of onset of a critical period of plasticity. Thus, particular neuronal networks defined by respective GABAA receptor subtypes can now be linked to the regulation of various clearly defined behavioural patterns. These achievements are of obvious relevance for the pharmacotherapy of certain brain disorders, in particular sleep dysfunctions, anxiety disorders, schizophrenia and diseases associated with memory deficits

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:1 November 2006
Deposited On:03 Dec 2018 16:18
Last Modified:24 Sep 2019 23:45
Publisher:Springer
ISSN:0302-766X
OA Status:Green
Publisher DOI:https://doi.org/10.1007/s00441-006-0284-3
Related URLs:https://www.swissbib.ch/Search/Results?lookfor=nationallicencespringer101007s0044100602843 (Library Catalogue)
PubMed ID:16937111

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