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Homer/Vesl Proteins and Their Roles in CNS Neurons


Ehrengruber, Markus U; Kato, Akihiko; Inokuchi, Kaoru; Hennou, Sonia (2004). Homer/Vesl Proteins and Their Roles in CNS Neurons. Molecular Neurobiology, 29(3):213-228.

Abstract

Since their initial discovery in 1997, Homer/Vesl proteins have become increasingly investigated as putative regulators of receptor and ion-channel function in the central nervous system. Within a relatively brief period, numerous research reports have described manifold effects of Homer proteins, including the modulation of the trafficking of type I metabotropic glutamate receptors (mGluRs), axonal pathfinding, mGluR coupling to calcium and potassium channels, agonist-independent mGluR activity, ryanodine receptor regulation, locomotor activity, and behavioral plasticity. This review summarizes our current knowledge on the induction, expression, and structure of the various forms of Homer proteins, as well as their roles in neuronal function. In addition, we provide an outlook on novel developments with regard to the involvement of Homer-1a in hippocampal synaptic function

Abstract

Since their initial discovery in 1997, Homer/Vesl proteins have become increasingly investigated as putative regulators of receptor and ion-channel function in the central nervous system. Within a relatively brief period, numerous research reports have described manifold effects of Homer proteins, including the modulation of the trafficking of type I metabotropic glutamate receptors (mGluRs), axonal pathfinding, mGluR coupling to calcium and potassium channels, agonist-independent mGluR activity, ryanodine receptor regulation, locomotor activity, and behavioral plasticity. This review summarizes our current knowledge on the induction, expression, and structure of the various forms of Homer proteins, as well as their roles in neuronal function. In addition, we provide an outlook on novel developments with regard to the involvement of Homer-1a in hippocampal synaptic function

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Life Sciences > Neurology
Life Sciences > Cellular and Molecular Neuroscience
Language:English
Date:1 January 2004
Deposited On:19 Oct 2018 08:36
Last Modified:31 Jul 2020 02:38
Publisher:Springer
ISSN:0893-7648
OA Status:Green
Publisher DOI:https://doi.org/10.1385/mn:29:3:213
Related URLs:https://www.swissbib.ch/Search/Results?lookfor=nationallicencespringer101385MN293213 (Library Catalogue)

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