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Inflammatory mediators and islet ?-cell failure: a link between type 1 and type 2 diabetes


Donath, Marc Y; Störling, Joachim; Maedler, Kathrin; Mandrup-Poulsen, Thomas (2003). Inflammatory mediators and islet ?-cell failure: a link between type 1 and type 2 diabetes. Journal of Molecular Medicine, 81(8):455-470.

Abstract

Pancreatic islet β-cell death occurs in type 1 and 2 diabetes mellitus, leading to absolute or relative insulin deficiency. β-cell death in type 1 diabetes is due predominantly to autoimmunity. In type 2 diabetes β-cell death occurs as the combined consequence of increased circulating glucose and saturated fatty acids together with adipocyte secreted factors and chronic activation of the innate immune system. In both diabetes types intra-islet inflammatory mediators seem to trigger a final common pathway leading to β-cell apoptosis. Therefore anti-inflammatory therapeutic approaches designed to block β-cell apoptosis could be a significant new development in type 1 and 2 diabetes

Abstract

Pancreatic islet β-cell death occurs in type 1 and 2 diabetes mellitus, leading to absolute or relative insulin deficiency. β-cell death in type 1 diabetes is due predominantly to autoimmunity. In type 2 diabetes β-cell death occurs as the combined consequence of increased circulating glucose and saturated fatty acids together with adipocyte secreted factors and chronic activation of the innate immune system. In both diabetes types intra-islet inflammatory mediators seem to trigger a final common pathway leading to β-cell apoptosis. Therefore anti-inflammatory therapeutic approaches designed to block β-cell apoptosis could be a significant new development in type 1 and 2 diabetes

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Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:1 August 2003
Deposited On:11 Oct 2018 11:22
Last Modified:17 Sep 2019 19:35
Publisher:Springer
ISSN:0946-2716
OA Status:Green
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1007/s00109-003-0450-y
Related URLs:https://www.swissbib.ch/Search/Results?lookfor=nationallicencespringer101007s001090030450y (Library Catalogue)

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