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Human insulinoma: clinical, cellular, and molecular aspects


Komminoth, Paul; Heitz, Philipp U; Roth, Jürgen (1999). Human insulinoma: clinical, cellular, and molecular aspects. Endocrine Pathology, 10(4):269-281.

Abstract

Insulinoma is the most frequently encountered functioning endocrine pancreatic tumor in humans. In this overview we summarize morphological and clinical features of insulinomas, report about the proinsulin-insulin conversion in normal and neoplastic B-cells, discuss the new classification, the criteria of malignancy, and the clonal composition of endocrine pancreatic tumors, and outline recent findings on the molecular pathology of these tumors

Abstract

Insulinoma is the most frequently encountered functioning endocrine pancreatic tumor in humans. In this overview we summarize morphological and clinical features of insulinomas, report about the proinsulin-insulin conversion in normal and neoplastic B-cells, discuss the new classification, the criteria of malignancy, and the clonal composition of endocrine pancreatic tumors, and outline recent findings on the molecular pathology of these tumors

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:Unspecified
Scopus Subject Areas:Health Sciences > Pathology and Forensic Medicine
Health Sciences > Endocrinology, Diabetes and Metabolism
Life Sciences > Endocrinology
Language:English
Date:1 December 1999
Deposited On:05 Dec 2018 19:23
Last Modified:31 Jul 2020 02:38
Publisher:Springer
ISSN:1046-3976
OA Status:Green
Publisher DOI:https://doi.org/10.1007/bf02739769
Related URLs:https://www.swissbib.ch/Search/Results?lookfor=nationallicencespringer101007BF02739769 (Library Catalogue)
PubMed ID:12114763

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