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A generalization of the van-der-Pol oscillator underlies active signal amplification in Drosophila hearing


Stoop, R; Kern, A; Göpfert, M C; Smirnov, D A; Dikanev, T V; Bezrucko, B P (2006). A generalization of the van-der-Pol oscillator underlies active signal amplification in Drosophila hearing. European biophysics journal : EBJ, 35(6):511-516.

Abstract

The antennal hearing organs of the fruit fly Drosophila melanogaster boost their sensitivity by an active mechanical process that, analogous to the cochlear amplifier of vertebrates, resides in the motility of mechanosensory cells. This process nonlinearly improves the sensitivity of hearing and occasionally gives rise to self-sustained oscillations in the absence of sound. Time series analysis of self-sustained oscillations now unveils that the underlying dynamical system is well described by a generalization of the van-der-Pol oscillator. From the dynamic equations, the underlying amplification dynamics can explicitly be derived. According to the model, oscillations emerge from a combination of negative damping, which reflects active amplification, and a nonlinear restoring force that dictates the amplitude of the oscillations. Hence, active amplification in fly hearing seems to rely on the negative damping mechanism initially proposed for the cochlear amplifier of vertebrates

Abstract

The antennal hearing organs of the fruit fly Drosophila melanogaster boost their sensitivity by an active mechanical process that, analogous to the cochlear amplifier of vertebrates, resides in the motility of mechanosensory cells. This process nonlinearly improves the sensitivity of hearing and occasionally gives rise to self-sustained oscillations in the absence of sound. Time series analysis of self-sustained oscillations now unveils that the underlying dynamical system is well described by a generalization of the van-der-Pol oscillator. From the dynamic equations, the underlying amplification dynamics can explicitly be derived. According to the model, oscillations emerge from a combination of negative damping, which reflects active amplification, and a nonlinear restoring force that dictates the amplitude of the oscillations. Hence, active amplification in fly hearing seems to rely on the negative damping mechanism initially proposed for the cochlear amplifier of vertebrates

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Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Scopus Subject Areas:Life Sciences > Biophysics
Language:English
Date:1 August 2006
Deposited On:09 Dec 2018 16:47
Last Modified:31 Jul 2020 02:39
Publisher:Springer
ISSN:0175-7571
OA Status:Green
Publisher DOI:https://doi.org/10.1007/s00249-006-0059-5
Related URLs:https://www.swissbib.ch/Search/Results?lookfor=nationallicencespringer101007s0024900600595 (Library Catalogue)
PubMed ID:16612585

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