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Molecular markers in gliomas: impact for the clinician


Hofer, Silvia; Lassman, Andrew B (2010). Molecular markers in gliomas: impact for the clinician. Targeted oncology, 5(3):201-210.

Abstract

Over the last decade, understanding of glioma on a molecular level has greatly expanded. However, optimal incorporation of molecular markers into clinical care is controversial. We briefly review the potential utility of molecular stratification in refining histologic diagnosis, prognosis, and treatment decisions, focussing on 1p/19q co-deletion, MGMT promoter methylation, EGFR mutations, and IDH mutation. The most recently discovered IDH mutation is a striking example of a rapid implementation of a molecular marker for prognostication into common clinical use

Abstract

Over the last decade, understanding of glioma on a molecular level has greatly expanded. However, optimal incorporation of molecular markers into clinical care is controversial. We briefly review the potential utility of molecular stratification in refining histologic diagnosis, prognosis, and treatment decisions, focussing on 1p/19q co-deletion, MGMT promoter methylation, EGFR mutations, and IDH mutation. The most recently discovered IDH mutation is a striking example of a rapid implementation of a molecular marker for prognostication into common clinical use

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:1 September 2010
Deposited On:13 Dec 2018 15:56
Last Modified:25 Apr 2019 09:28
Publisher:Springer
ISSN:1776-2596
OA Status:Green
Publisher DOI:https://doi.org/10.1007/s11523-010-0157-2
Related URLs:https://www.swissbib.ch/Search/Results?lookfor=nationallicencespringer101007s1152301001572 (Library Catalogue)
PubMed ID:20809335

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