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Towards an understanding of electrogenic cotransporters: structure-function relationships


Forster, Ian C (2001). Towards an understanding of electrogenic cotransporters: structure-function relationships. Pflügers Archiv : European Journal of Physiology, 443(2):163-165.

Abstract

In this animal study we evaluated the dependence of the pulmonary diffusing capacity (D L) of nitric oxide (D L,NO) on ventilator-driven increases in alveolar volume. According to the common hypothesis as to whether D L,NO reflects the diffusive properties of the alveolar-capillary membrane, D L,NO should be improved by lung expansion. However, the influence of a simultaneous raise in intrapulmonary pressure is unknown. D L,NO was determined by applying the single-breath method to four anaesthetised paralysed rabbits (weight 3.2-3.5kg) at various alveolar volumes (38-69ml) and intrapulmonary pressures (0.15-12.5mmHg). The animals were ventilated with room air, using a computerised ventilatory servo-system that was also employed to perform the single-breath manoeuvres. Inflation procedures were always started from residual volume (12-13.7ml), using 0.05% NO in N2 as the indicator gas mixture. End-tidal PNO was determined by respiratory mass spectrometry. D L,NO increased simultaneously with lung expansion and with increasing intrapulmonary pressure (P<0.001). We conclude that the D L,NO provides a measure of the pulmonary diffusive properties that is not influenced by a pressure-induced impairment of pulmonary capillary blood flow

Abstract

In this animal study we evaluated the dependence of the pulmonary diffusing capacity (D L) of nitric oxide (D L,NO) on ventilator-driven increases in alveolar volume. According to the common hypothesis as to whether D L,NO reflects the diffusive properties of the alveolar-capillary membrane, D L,NO should be improved by lung expansion. However, the influence of a simultaneous raise in intrapulmonary pressure is unknown. D L,NO was determined by applying the single-breath method to four anaesthetised paralysed rabbits (weight 3.2-3.5kg) at various alveolar volumes (38-69ml) and intrapulmonary pressures (0.15-12.5mmHg). The animals were ventilated with room air, using a computerised ventilatory servo-system that was also employed to perform the single-breath manoeuvres. Inflation procedures were always started from residual volume (12-13.7ml), using 0.05% NO in N2 as the indicator gas mixture. End-tidal PNO was determined by respiratory mass spectrometry. D L,NO increased simultaneously with lung expansion and with increasing intrapulmonary pressure (P<0.001). We conclude that the D L,NO provides a measure of the pulmonary diffusive properties that is not influenced by a pressure-induced impairment of pulmonary capillary blood flow

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Scopus Subject Areas:Life Sciences > Physiology
Life Sciences > Clinical Biochemistry
Health Sciences > Physiology (medical)
Language:English
Date:1 November 2001
Deposited On:26 Sep 2018 13:16
Last Modified:15 Apr 2021 14:53
Publisher:Springer
ISSN:0031-6768
OA Status:Green
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1007/s004240100722

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