Header

UZH-Logo

Maintenance Infos

Valaciclovir for Chronic Hepatitis B Virus Infection after Lung Transplantation


Laube, I; Boehler, A; Renner, E L; Speich, R (2004). Valaciclovir for Chronic Hepatitis B Virus Infection after Lung Transplantation. Infection, 32(1):51-53.

Abstract

We report on a chronic asymptomatic hepatitis B surface antigen (HBsAg) carrier who developed an increase in aminotransferase and HBsAg levels 1 year after lung transplantation. During treatment for cutaneous herpes simplex virus (HSV) infection with oral valaciclovir there was a marked decrease in replicating hepatitis B virus (HBV)-DNA and aminotransferase levels, which was sustained for 9 months by continuing low-dose valaciclovir. A second rise in aminotransferase levels again responded to a valaciclovir dose increase and the HBV-DNA levels declined further. Although we cannot exclude a spontaneous variation of the serologic parameters, our observation suggests that valaciclovir may represent a valuable therapeutic option in the treatment of chronic hepatitis B after lung transplantation

Abstract

We report on a chronic asymptomatic hepatitis B surface antigen (HBsAg) carrier who developed an increase in aminotransferase and HBsAg levels 1 year after lung transplantation. During treatment for cutaneous herpes simplex virus (HSV) infection with oral valaciclovir there was a marked decrease in replicating hepatitis B virus (HBV)-DNA and aminotransferase levels, which was sustained for 9 months by continuing low-dose valaciclovir. A second rise in aminotransferase levels again responded to a valaciclovir dose increase and the HBV-DNA levels declined further. Although we cannot exclude a spontaneous variation of the serologic parameters, our observation suggests that valaciclovir may represent a valuable therapeutic option in the treatment of chronic hepatitis B after lung transplantation

Statistics

Citations

Dimensions.ai Metrics
1 citation in Web of Science®
1 citation in Scopus®
Google Scholar™

Altmetrics

Downloads

2 downloads since deposited on 19 Oct 2018
2 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:Unspecified
Language:English
Date:1 February 2004
Deposited On:19 Oct 2018 11:43
Last Modified:20 Oct 2018 01:02
Publisher:Springer
ISSN:0300-8126
OA Status:Green
Publisher DOI:https://doi.org/10.1007/s15010-003-3094-5
Related URLs:https://www.swissbib.ch/Search/Results?lookfor=nationallicencespringer101007s1501000330945 (Library Catalogue)

Download

Download PDF  'Valaciclovir for Chronic Hepatitis B Virus Infection after Lung Transplantation'.
Preview
Content: Published Version
Language: English
Filetype: PDF (Nationallizenz 142-005)
Size: 264kB
View at publisher