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Safety of lumbar puncture for adults with acute leukemia and restrictive prophylactic platelet transfusio


Vavricka, Stephan R; Walter, Roland B; Irani, Sarosh; Halter, Joerg; Schanz, Urs (2003). Safety of lumbar puncture for adults with acute leukemia and restrictive prophylactic platelet transfusio. Annals of Hematology, 82(9):570-573.

Abstract

No data exist on the trigger for platelet transfusions in adult thrombocytopenic patients with acute leukemia undergoing lumbar puncture (LP). We reviewed the records of 66 patients with acute leukemia (median age 38years, range 18-68) who have been treated in our institution for 6years. A total of 195 LPs were performed. No serious hemorrhagic complications occurred, but there was a significant trend towards a higher percentage of traumatic procedures, defined as the occurrence of >500 erythrocytes per high-power field, in patients with lowest platelet counts (p<0.005). Although not associated with serious clinical bleeding events in this study, the increased occurrence of traumatic procedures may indicate an increased risk for more serious hemorrhagic complications, implying a trigger not lower than 20×109/L for prophylactic transfusions of platelets in adult patients with acute leukemia undergoing LP

Abstract

No data exist on the trigger for platelet transfusions in adult thrombocytopenic patients with acute leukemia undergoing lumbar puncture (LP). We reviewed the records of 66 patients with acute leukemia (median age 38years, range 18-68) who have been treated in our institution for 6years. A total of 195 LPs were performed. No serious hemorrhagic complications occurred, but there was a significant trend towards a higher percentage of traumatic procedures, defined as the occurrence of >500 erythrocytes per high-power field, in patients with lowest platelet counts (p<0.005). Although not associated with serious clinical bleeding events in this study, the increased occurrence of traumatic procedures may indicate an increased risk for more serious hemorrhagic complications, implying a trigger not lower than 20×109/L for prophylactic transfusions of platelets in adult patients with acute leukemia undergoing LP

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:1 September 2003
Deposited On:11 Oct 2018 12:51
Last Modified:11 Oct 2018 12:51
Publisher:Springer
ISSN:0939-5555
OA Status:Green
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1007/s00277-003-0707-0
Related URLs:https://www.swissbib.ch/Search/Results?lookfor=nationallicencespringer101007s0027700307070 (Library Catalogue)

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