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l-Carnitine and the recovery from exhaustive endurance exercise: a randomised, double-blind, placebo-controlled trial


Stuessi, Christoph; Hofer, Pierre; Meier, Christian; Boutellier, Urs (2005). l-Carnitine and the recovery from exhaustive endurance exercise: a randomised, double-blind, placebo-controlled trial. European Journal of Applied Physiology, 95(5-6):431-435.

Abstract

We hypothesised that l-carnitine could accelerate recovery from exhaustive exercise since increased blood l-carnitine concentrations elicit a vasodilation in isolated animal vessels as well as in patients with peripheral vascular or coronary artery disease during exercise. Twelve subjects received either 2g l-carnitine or a placebo in a study which was double-blind and crossover in design. Two hours after administration, the subjects performed a constant-load exercise test (CET1) cycling at their individual anaerobic threshold to exhaustion. Three hours later this test was repeated (CET2). After 4-14 days, each subject performed the same cycling tests after having taken the other substance. Exercise times of the 12 subjects were identical with l-carnitine (CET1: 21.3±5.7min; CET2: 21.4±5.3min) and placebo (CET1: 21.9±6.2min; CET2: 20.4±4.8min). Also, heart rate, oxygen consumption, respiratory exchange ratio, and blood lactate concentration were identical. In conclusion, 2g of L-carnitine taken 2h before a first of two constant-load exercise tests had no influence on the second tests performed 3h after the first test compared with placebo

Abstract

We hypothesised that l-carnitine could accelerate recovery from exhaustive exercise since increased blood l-carnitine concentrations elicit a vasodilation in isolated animal vessels as well as in patients with peripheral vascular or coronary artery disease during exercise. Twelve subjects received either 2g l-carnitine or a placebo in a study which was double-blind and crossover in design. Two hours after administration, the subjects performed a constant-load exercise test (CET1) cycling at their individual anaerobic threshold to exhaustion. Three hours later this test was repeated (CET2). After 4-14 days, each subject performed the same cycling tests after having taken the other substance. Exercise times of the 12 subjects were identical with l-carnitine (CET1: 21.3±5.7min; CET2: 21.4±5.3min) and placebo (CET1: 21.9±6.2min; CET2: 20.4±4.8min). Also, heart rate, oxygen consumption, respiratory exchange ratio, and blood lactate concentration were identical. In conclusion, 2g of L-carnitine taken 2h before a first of two constant-load exercise tests had no influence on the second tests performed 3h after the first test compared with placebo

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Scopus Subject Areas:Health Sciences > Orthopedics and Sports Medicine
Health Sciences > Public Health, Environmental and Occupational Health
Health Sciences > Physiology (medical)
Language:English
Date:1 December 2005
Deposited On:24 Oct 2018 13:40
Last Modified:31 Jul 2020 02:45
Publisher:Springer
ISSN:1439-6319
OA Status:Green
Publisher DOI:https://doi.org/10.1007/s00421-005-0020-9
Related URLs:https://www.swissbib.ch/Search/Results?lookfor=nationallicencespringer101007s0042100500209 (Library Catalogue)

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