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Adult neurogenesis in the mammalian brain


Braun, Simon M G; Jessberger, Sebastian (2013). Adult neurogenesis in the mammalian brain. Frontiers in Biology, 8(3):295-304.

Abstract

New neurons are generated throughout life in distinct areas of the mammalian brain. This process, called adult neurogenesis, has challenged previously held concepts about adult brain plasticity and opened novel therapeutic avenues to treat certain neuro-psychiatric diseases. Here, we review the current knowledge regarding the fate and potency of neural stem cells (NSCs), as well as the mechanisms underlying neuronal differentiation and subsequent integration. Furthermore, we discuss the functional significance of adult neurogenesis in health and disease, and offer brief insight into the future directions of the adult neurogenesis field

Abstract

New neurons are generated throughout life in distinct areas of the mammalian brain. This process, called adult neurogenesis, has challenged previously held concepts about adult brain plasticity and opened novel therapeutic avenues to treat certain neuro-psychiatric diseases. Here, we review the current knowledge regarding the fate and potency of neural stem cells (NSCs), as well as the mechanisms underlying neuronal differentiation and subsequent integration. Furthermore, we discuss the functional significance of adult neurogenesis in health and disease, and offer brief insight into the future directions of the adult neurogenesis field

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Scopus Subject Areas:Life Sciences > Biotechnology
Life Sciences > Ecology, Evolution, Behavior and Systematics
Physical Sciences > Ecology
Life Sciences > Genetics
Language:English
Date:1 June 2013
Deposited On:19 Dec 2018 15:18
Last Modified:15 Apr 2021 14:54
Publisher:Springer
ISSN:1674-7984
OA Status:Green
Publisher DOI:https://doi.org/10.1007/s11515-013-1263-1

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Language: English
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