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Phosphate concentration in artificial tears


Bernauer, Wolfgang; Thiel, M A; Langenauer, U M; Rentsch, K M (2006). Phosphate concentration in artificial tears. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie, 244(8):1010-1014.

Abstract

Background: Irrigating solutions and eye drops may contain phosphates as part of their buffer system. In the presence of epithelial keratopathy, a high concentration of phosphate favours corneal calcification. Knowledge of the phosphate concentration in artificial tear products helps to prevent this sight-threatening complication. This study gives an overview on the amount of phosphate contained in artificial tears. Methods: Fifty-nine samples of commercially available artificial tear preparations were tested. The quantification of phosphate was performed using the molybdate method on a Modular P autoanalyzer. Results: Twenty-six of 59 (44%) artificial tear products had a phosphate concentration above physiological levels (>1.45mmol/l). A phosphate concentration above 25mmol/l was found in nine products (15%), a concentration higher than 50mmol/l in three (5%). Conclusions: Many artificial tear formulations contain unphysiological levels of phosphate, but very high concentrations are found only in a few products. These preparations have the potential to favour the formation of insoluble crystalline calcium phosphate deposits when used on a damaged corneal surface, and should therefore be used cautiously

Abstract

Background: Irrigating solutions and eye drops may contain phosphates as part of their buffer system. In the presence of epithelial keratopathy, a high concentration of phosphate favours corneal calcification. Knowledge of the phosphate concentration in artificial tear products helps to prevent this sight-threatening complication. This study gives an overview on the amount of phosphate contained in artificial tears. Methods: Fifty-nine samples of commercially available artificial tear preparations were tested. The quantification of phosphate was performed using the molybdate method on a Modular P autoanalyzer. Results: Twenty-six of 59 (44%) artificial tear products had a phosphate concentration above physiological levels (>1.45mmol/l). A phosphate concentration above 25mmol/l was found in nine products (15%), a concentration higher than 50mmol/l in three (5%). Conclusions: Many artificial tear formulations contain unphysiological levels of phosphate, but very high concentrations are found only in a few products. These preparations have the potential to favour the formation of insoluble crystalline calcium phosphate deposits when used on a damaged corneal surface, and should therefore be used cautiously

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Ophthalmology
Life Sciences > Sensory Systems
Life Sciences > Cellular and Molecular Neuroscience
Language:English
Date:1 August 2006
Deposited On:19 Dec 2018 15:30
Last Modified:15 Apr 2021 14:54
Publisher:Springer
ISSN:0721-832X
OA Status:Green
Publisher DOI:https://doi.org/10.1007/s00417-005-0219-9
PubMed ID:16418839

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