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CSF prostaglandin D synthase is reduced in excessive daytime sleepiness


Bassetti, Claudio L; Hersberger, Martin; Baumann, Christian R (2006). CSF prostaglandin D synthase is reduced in excessive daytime sleepiness. Journal of Neurology, 253(8):1030-1033.

Abstract

Lipocalin-type prostaglandin D synthase (L-PGDS) is a brain enzyme, which produces prostaglandin D2, a substance with endogenous somnogenic effects. Using a standardized protocol for immunonephelometric determination of cerebrospinal fluid (CSF) L-PGDS levels, we show that CSF L-PGDS levels are significantly lower in 34 patients with excessive daytime sleepiness when compared with levels in 22 healthy controls. Thus, L-PGDS may represent the first neurochemical measure of excessive daytime sleepiness

Abstract

Lipocalin-type prostaglandin D synthase (L-PGDS) is a brain enzyme, which produces prostaglandin D2, a substance with endogenous somnogenic effects. Using a standardized protocol for immunonephelometric determination of cerebrospinal fluid (CSF) L-PGDS levels, we show that CSF L-PGDS levels are significantly lower in 34 patients with excessive daytime sleepiness when compared with levels in 22 healthy controls. Thus, L-PGDS may represent the first neurochemical measure of excessive daytime sleepiness

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Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:1 August 2006
Deposited On:03 Jul 2019 13:12
Last Modified:24 Sep 2019 23:47
Publisher:Springer
ISSN:0340-5354
OA Status:Green
Publisher DOI:https://doi.org/10.1007/s00415-006-0153-8
Related URLs:https://www.swissbib.ch/Search/Results?lookfor=nationallicencespringer101007s0041500601538 (Library Catalogue)
PubMed ID:16598611

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