Navigation auf zora.uzh.ch

Search ZORA

ZORA (Zurich Open Repository and Archive)

Migration von ZORA auf die Software DSpace

ZORA will change to a new software on 8th September 2025. Please note: deadline for new submissions is 21th July 2025!

Information & dates for training courses can be found here: Information on Software Migration.

Hypertonicity induced apoptosis in HL-60 cells in the presence of intracellular potassium

Ghosh, Arko; Keng, Peter C; Knauf, Philip A (2007). Hypertonicity induced apoptosis in HL-60 cells in the presence of intracellular potassium. Apoptosis, 12(7):1281-1288.

Abstract

Cell shrinkage is a hallmark of apoptosis. Potassium efflux, which is involved in cell shrinkage, has been previously described as an essential event of apoptosis. This study was designed to address the importance of potassium efflux in hypertonicity (450 mOsm and 600 mOsm) induced apoptosis. We initiated apoptosis in HL-60 cells in hypertonic medium consisting of either high concentrations of NaCl, mannitol or KCl. Apoptotic activity was evaluated based on the DNA content of the cells, annexin-V staining and calcium content. Apoptosis was initiated in hypertonic conditions consisting of high intracellular K+. We demonstrate that apoptosis can occur in the presence of high intracellular potassium contrary to previous predictions

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Scopus Subject Areas:Life Sciences > Pharmacology
Life Sciences > Pharmaceutical Science
Life Sciences > Clinical Biochemistry
Life Sciences > Cell Biology
Health Sciences > Biochemistry (medical)
Life Sciences > Cancer Research
Language:English
Date:8 June 2007
Deposited On:03 Jul 2019 13:18
Last Modified:18 Jun 2025 01:40
Publisher:Springer
ISSN:1360-8185
OA Status:Green
Publisher DOI:https://doi.org/10.1007/s10495-007-0054-z
PubMed ID:17333319
Download PDF  'Hypertonicity induced apoptosis in HL-60 cells in the presence of intracellular potassium'.
Preview
  • Content: Published Version
  • Language: English
  • Description: Nationallizenz 142-005

Metadata Export

Statistics

Citations

Dimensions.ai Metrics
3 citations in Web of Science®
5 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

52 downloads since deposited on 03 Jul 2019
12 downloads since 12 months
Detailed statistics

Authors, Affiliations, Collaborations

Similar Publications