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Utrophin is lacking at the neuromuscular junctions in the extraocular muscles of normal cat: artefact or true?


Assadi, Maziar; Müntener, Markus (2005). Utrophin is lacking at the neuromuscular junctions in the extraocular muscles of normal cat: artefact or true? Histochemistry and Cell Biology, 123(2):189-194.

Abstract

Extraocular muscles (EOM) are typically spared in Duchenne muscular dystrophy. We hypothesized that this might be due to different patterns of utrophin expression. The expression of utrophin was examined in EOM of normal cats using immunohistochemical methods and Western blot. For detecting acetylcholine receptors (AChR), we used α-bungarotoxin. Surprisingly, α-bungarotoxin failed to stain the AChR and no expression of utrophin could be detected at the neuromuscular junctions. Our study could indicate that the expression of utrophin is dependent on the structure of the AChR

Abstract

Extraocular muscles (EOM) are typically spared in Duchenne muscular dystrophy. We hypothesized that this might be due to different patterns of utrophin expression. The expression of utrophin was examined in EOM of normal cats using immunohistochemical methods and Western blot. For detecting acetylcholine receptors (AChR), we used α-bungarotoxin. Surprisingly, α-bungarotoxin failed to stain the AChR and no expression of utrophin could be detected at the neuromuscular junctions. Our study could indicate that the expression of utrophin is dependent on the structure of the AChR

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Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Scopus Subject Areas:Health Sciences > Histology
Life Sciences > Molecular Biology
Health Sciences > Medical Laboratory Technology
Life Sciences > Cell Biology
Language:English
Date:1 February 2005
Deposited On:04 Jul 2019 11:04
Last Modified:31 Jul 2020 02:50
Publisher:Springer
ISSN:0948-6143
OA Status:Green
Publisher DOI:https://doi.org/10.1007/s00418-005-0762-9
Related URLs:https://www.swissbib.ch/Search/Results?lookfor=nationallicencespringer101007s0041800507629 (Library Catalogue)
PubMed ID:15729554

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