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Human endothelial dysfunction: EDRFs


Flammer, Andreas J; Lüscher, Thomas F (2010). Human endothelial dysfunction: EDRFs. Pflügers Archiv : European Journal of Physiology, 459(6):1005-1013.

Abstract

Since the detection of nitric oxide two and a half decades ago, there has been an incredible boost in endothelial function research, which is fascinating the research community. Physiologically, endothelial cells synthesize a number of vasoactive substances. In particular, several endothelium-derived relaxing factors (EDRFs) have been characterized, whereby nitric oxide is the most important. In humans, endothelial dysfunction is one of the first clinically detectable alterations in the development of atherosclerosis and is characterized by an imbalance in the release of vasoactive substances. Thus, it is the aim of this article to give an overview about endothelial function in humans, to summarize the different possibilities to assess endothelial function in this species, and to give an overview of the role of EDRFs in different cardiovascular diseases

Abstract

Since the detection of nitric oxide two and a half decades ago, there has been an incredible boost in endothelial function research, which is fascinating the research community. Physiologically, endothelial cells synthesize a number of vasoactive substances. In particular, several endothelium-derived relaxing factors (EDRFs) have been characterized, whereby nitric oxide is the most important. In humans, endothelial dysfunction is one of the first clinically detectable alterations in the development of atherosclerosis and is characterized by an imbalance in the release of vasoactive substances. Thus, it is the aim of this article to give an overview about endothelial function in humans, to summarize the different possibilities to assess endothelial function in this species, and to give an overview of the role of EDRFs in different cardiovascular diseases

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Additional indexing

Item Type:Journal Article, refereed
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Scopus Subject Areas:Life Sciences > Physiology
Life Sciences > Clinical Biochemistry
Health Sciences > Physiology (medical)
Language:English
Date:1 May 2010
Deposited On:04 Jul 2019 14:49
Last Modified:31 Jul 2020 02:51
Publisher:Springer
ISSN:0031-6768
OA Status:Green
Publisher DOI:https://doi.org/10.1007/s00424-010-0822-4
Related URLs:https://www.swissbib.ch/Search/Results?lookfor=nationallicencespringer101007s0042401008224 (Library Catalogue)
PubMed ID:20383717

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