Header

UZH-Logo

Maintenance Infos

Early maternal care may counteract familial liability for psychopathology in the reward circuitry


Holz, Nathalie E; Boecker-Schlier, Regina; Jennen-Steinmetz, Christine; Hohm, Erika; Buchmann, Arlette F; Blomeyer, Dorothea; Baumeister, Sarah; Plichta, Michael M; Esser, Günter; Schmidt, Martin; Meyer-Lindenberg, Andreas; Banaschewski, Tobias; Brandeis, Daniel; Laucht, Manfred (2018). Early maternal care may counteract familial liability for psychopathology in the reward circuitry. Social Cognitive and Affective Neuroscience, 13(11):1191-1201.

Abstract

Reward processing is altered in various psychopathologies and has been shown to be susceptible to genetic and environmental influences. Here, we examined whether maternal care may buffer familial risk for psychiatric disorders in terms of reward processing.Functional MRI during a monetary incentive delay task was acquired in participants of an epidemiological cohort study followed since birth (N=172, 25 years). Early maternal stimulation was assessed during a standardized nursing/playing setting at the age of 3 months. Parental psychiatric disorders (familial risk) during childhood and the participants' previous psychopathology were assessed by diagnostic interview.With high familial risk, higher maternal stimulation was related to increasing activation in the caudate head, the supplementary motor area, the cingulum and the middle frontal gyrus during reward anticipation, with the opposite pattern found in individuals with no familial risk. In contrast, higher maternal stimulation was associated with decreasing caudate head activity during reward delivery and reduced levels of ADHD in the high-risk group. Decreased caudate head activity during reward anticipation and increased activity during delivery were linked to ADHD.These findings provide evidence of a long-term association of early maternal stimulation on both adult neurobiological systems of reward underlying externalizing behavior and ADHD during development.

Abstract

Reward processing is altered in various psychopathologies and has been shown to be susceptible to genetic and environmental influences. Here, we examined whether maternal care may buffer familial risk for psychiatric disorders in terms of reward processing.Functional MRI during a monetary incentive delay task was acquired in participants of an epidemiological cohort study followed since birth (N=172, 25 years). Early maternal stimulation was assessed during a standardized nursing/playing setting at the age of 3 months. Parental psychiatric disorders (familial risk) during childhood and the participants' previous psychopathology were assessed by diagnostic interview.With high familial risk, higher maternal stimulation was related to increasing activation in the caudate head, the supplementary motor area, the cingulum and the middle frontal gyrus during reward anticipation, with the opposite pattern found in individuals with no familial risk. In contrast, higher maternal stimulation was associated with decreasing caudate head activity during reward delivery and reduced levels of ADHD in the high-risk group. Decreased caudate head activity during reward anticipation and increased activity during delivery were linked to ADHD.These findings provide evidence of a long-term association of early maternal stimulation on both adult neurobiological systems of reward underlying externalizing behavior and ADHD during development.

Statistics

Citations

Dimensions.ai Metrics

Altmetrics

Downloads

8 downloads since deposited on 25 Oct 2018
8 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Psychiatric University Hospital Zurich > Department of Child and Adolescent Psychiatry
04 Faculty of Medicine > Neuroscience Center Zurich
04 Faculty of Medicine > Center for Integrative Human Physiology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:8 November 2018
Deposited On:25 Oct 2018 09:03
Last Modified:29 Sep 2019 05:53
Publisher:Oxford University Press
ISSN:1749-5016
OA Status:Gold
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1093/scan/nsy087
PubMed ID:30257014
Project Information:
  • : FunderFP7
  • : Grant ID602805
  • : Project TitleAggression subtyping for improved insight and treatment innovation in psychiatric disorders
  • : FunderFP7
  • : Grant ID603016
  • : Project TitleMultidisciplinary Approaches to Translational Research In Conduct Syndromes
  • : FunderDFG
  • : Grant IDHO 5674/2-1
  • : Project TitleExploring the long-term impact of early life adversity on the (anti-)social brain

Download

Download PDF  'Early maternal care may counteract familial liability for psychopathology in the reward circuitry'.
Preview
Content: Published Version
Filetype: PDF
Size: 8MB
View at publisher
Licence: Creative Commons: Attribution 4.0 International (CC BY 4.0)
Download PDF  'Early maternal care may counteract familial liability for psychopathology in the reward circuitry'.
Preview
Content: Accepted Version
Language: English
Filetype: PDF
Size: 449kB