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The Etiological Structure of Cognitive-Neurophysiological Impairments in ADHD in Adolescence and Young Adulthood


Michelini, Giorgia; Cheung, Celeste H M; Kitsune, Viryanaga; Brandeis, Daniel; Banaschewski, Tobias; McLoughlin, Gráinne; Asherson, Philip; Rijsdijk, Frühling; Kuntsi, Jonna (2018). The Etiological Structure of Cognitive-Neurophysiological Impairments in ADHD in Adolescence and Young Adulthood. Journal of attention disorders:Epub ahead of print.

Abstract

OBJECTIVE Previous studies in children with ADHD identified two partially separable familial factors underlying cognitive dysfunction, but evidence in adolescents and adults is lacking. Here, we investigate the etiological structure of cognitive-neurophysiological impairments in ADHD in adolescents and young adults. METHOD Factor analyses and multivariate familial models were run in 356 participants from ADHD and control sibling pairs aged 11 to 27 years on data on IQ, digit span forward (DSF) and backward (DSB), and cognitive-performance and event-related potential (ERP) measures from three cognitive tasks. RESULTS Three familial factors (cF), showing substantial familial overlap with ADHD, captured the familial covariation of ADHD with nine cognitive-ERP measures. cF loaded on IQ, mean reaction time (MRT), and reaction-time variability (RTV); cF on DSF and DSB; and cF on number of errors and ERPs of inhibition and error processing. CONCLUSION These results identify three partially separable etiological pathways leading to cognitive-neurophysiological impairments in adolescent and adult ADHD.

Abstract

OBJECTIVE Previous studies in children with ADHD identified two partially separable familial factors underlying cognitive dysfunction, but evidence in adolescents and adults is lacking. Here, we investigate the etiological structure of cognitive-neurophysiological impairments in ADHD in adolescents and young adults. METHOD Factor analyses and multivariate familial models were run in 356 participants from ADHD and control sibling pairs aged 11 to 27 years on data on IQ, digit span forward (DSF) and backward (DSB), and cognitive-performance and event-related potential (ERP) measures from three cognitive tasks. RESULTS Three familial factors (cF), showing substantial familial overlap with ADHD, captured the familial covariation of ADHD with nine cognitive-ERP measures. cF loaded on IQ, mean reaction time (MRT), and reaction-time variability (RTV); cF on DSF and DSB; and cF on number of errors and ERPs of inhibition and error processing. CONCLUSION These results identify three partially separable etiological pathways leading to cognitive-neurophysiological impairments in adolescent and adult ADHD.

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Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Psychiatric University Hospital Zurich > Department of Child and Adolescent Psychiatry
04 Faculty of Medicine > Neuroscience Center Zurich
04 Faculty of Medicine > Center for Integrative Human Physiology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:1 May 2018
Deposited On:25 Oct 2018 09:29
Last Modified:12 Sep 2020 11:04
Publisher:Sage Publications Ltd.
ISSN:1087-0547
OA Status:Hybrid
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1177/1087054718771191
PubMed ID:29720024

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