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Feasibility of an 8-item questionnaire for early diagnosis of inflammatory bowel disease in primary care


Chmiel, Corinne; Vavricka, Stephan R; Hasler, Susann; Rogler, Gerhard; Zahnd, Nadine; Schiesser, Salomé; Tandjung, Ryan; Scherz, Nathalie; Rosemann, Thomas; Senn, Oliver (2019). Feasibility of an 8-item questionnaire for early diagnosis of inflammatory bowel disease in primary care. Journal of Evaluation in Clinical Practice, 25(1):155-162.

Abstract

Aims Diagnosis of inflammatory bowel disease (IBD) is often associated with a diagnostic delay. Although faecal calprotectin is a helpful screening tool, the widespread use in primary care (PC) may not be appropriate due to the low prevalence of IBD in this setting. To increase pretest probability for a positive calprotectin test, an 8‐item questionnaire (CalproQuest) was tested for its feasibility and acceptability in PC. Methods Population: PC patients with unspecific gastrointestinal complaints for at least 2 weeks. The CalproQuest consists of four major and four minor questions specific for IBD. It is considered positive if greater than or equal to two major or one major and two minor criteria are positive. Primary outcome: feasibility of CalproQuest, secondary outcome: patient's acceptance of stool sampling. Results Of 95 patients with a complete CalproQuest 52 (54.7%) were positive, 39 (41.1%) fulfilled two major and 13 (13.7%) one major and greater than or equal to two minor criteria. Twenty‐seven general practitioners completed 83 (87.4%) questionnaires on feasibility which was assessed positive. Eighty‐two patients (86.3%) completed questionnaires on acceptance which was high. Conclusion The CalproQuest is a feasible instrument for assessing IBD in PC. Further prospective studies concerning validity and cost effectiveness of a combined use with the calprotectin test in this setting are necessary.

Abstract

Aims Diagnosis of inflammatory bowel disease (IBD) is often associated with a diagnostic delay. Although faecal calprotectin is a helpful screening tool, the widespread use in primary care (PC) may not be appropriate due to the low prevalence of IBD in this setting. To increase pretest probability for a positive calprotectin test, an 8‐item questionnaire (CalproQuest) was tested for its feasibility and acceptability in PC. Methods Population: PC patients with unspecific gastrointestinal complaints for at least 2 weeks. The CalproQuest consists of four major and four minor questions specific for IBD. It is considered positive if greater than or equal to two major or one major and two minor criteria are positive. Primary outcome: feasibility of CalproQuest, secondary outcome: patient's acceptance of stool sampling. Results Of 95 patients with a complete CalproQuest 52 (54.7%) were positive, 39 (41.1%) fulfilled two major and 13 (13.7%) one major and greater than or equal to two minor criteria. Twenty‐seven general practitioners completed 83 (87.4%) questionnaires on feasibility which was assessed positive. Eighty‐two patients (86.3%) completed questionnaires on acceptance which was high. Conclusion The CalproQuest is a feasible instrument for assessing IBD in PC. Further prospective studies concerning validity and cost effectiveness of a combined use with the calprotectin test in this setting are necessary.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Gastroenterology and Hepatology
04 Faculty of Medicine > University Hospital Zurich > Institute of General Practice
Dewey Decimal Classification:610 Medicine & health
Uncontrolled Keywords:Public Health, Environmental and Occupational Health, Health Policy
Language:English
Date:1 February 2019
Deposited On:25 Oct 2018 13:02
Last Modified:11 Jan 2019 02:03
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:1356-1294
OA Status:Closed
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1111/jep.13046
PubMed ID:30324695

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