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Secondary pleuroparenchymal fibro-elastosis with airway-centered fibro-elastosis and con-strictive bronchiolitis associated with agriculture dust exposure


Vrugt, Bart; Frauenfelder, Thomas; Dressel, Holger; Barresi, Fabio; Clarenbach, Christian; Kuhn, Barbara (2018). Secondary pleuroparenchymal fibro-elastosis with airway-centered fibro-elastosis and con-strictive bronchiolitis associated with agriculture dust exposure. Case Reports in Clinical Pathology, 5(1):4.

Abstract

Pleuroparenchymal fibro-elastosis (PPFE) is a rare idiopathic interstitial pneumonia. Secondary forms of PPFE may occur in patients following lung- or bone marrow transplantation. Here we report a middle-aged woman who presented with dyspnea and cough. She had been working as a cleaning woman in an agriculture company and logistic firm. Chest HRCT was highly suggestive for PPFE. Histopathological examination of a surgical biopsy showed a pattern of PPFE with airway-centered fibro-elastosis, constrictive bronchiolitis and birefringent particles in the pathological areas only. Using transmission electron microscopy with X-ray diffraction (TEM/EDX) these particles were identified as quartz and silicates, both components generally found in soil. The present case illustrates that secondary PPFE may result from agricultural dust exposure and stresses the need for a careful workup of the occupational history.

Abstract

Pleuroparenchymal fibro-elastosis (PPFE) is a rare idiopathic interstitial pneumonia. Secondary forms of PPFE may occur in patients following lung- or bone marrow transplantation. Here we report a middle-aged woman who presented with dyspnea and cough. She had been working as a cleaning woman in an agriculture company and logistic firm. Chest HRCT was highly suggestive for PPFE. Histopathological examination of a surgical biopsy showed a pattern of PPFE with airway-centered fibro-elastosis, constrictive bronchiolitis and birefringent particles in the pathological areas only. Using transmission electron microscopy with X-ray diffraction (TEM/EDX) these particles were identified as quartz and silicates, both components generally found in soil. The present case illustrates that secondary PPFE may result from agricultural dust exposure and stresses the need for a careful workup of the occupational history.

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Additional indexing

Item Type:Journal Article, not_refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Pathology and Molecular Pathology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:24 April 2018
Deposited On:23 Oct 2018 13:37
Last Modified:30 Oct 2018 16:13
Publisher:Sciedu Press
ISSN:2331-2726
OA Status:Closed
Publisher DOI:https://doi.org/10.5430/crcp.v5n1p4

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