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Altered miRNA-4321 expression in maternal and foetal placenta of intrauterine growth restricted bovine foetuses


Rutkowska, Karolina; Stachowiak, Monika; Oprzadek, Jolanta; Bauersachs, Stefan; Flisikowski, Krzysztof (2018). Altered miRNA-4321 expression in maternal and foetal placenta of intrauterine growth restricted bovine foetuses. Placenta, 70:50-52.

Abstract

Intrauterine growth restriction (IUGR) is a serious pregnancy complication caused by placental insufficiency. We previously reported that truncation of MIMT1 gene exons 3 and 4 (MIMT1Del) causes IUGR in cattle. Here we investigated miRNA expression in the foetal and maternal placenta tissues of MIMT1Del/WT foetuses. Small RNA next generation sequencing and quantitative PCR revealed placental tissue-specific expression of the miR-4321, known to regulate many genes involved in early foetal development. This study also indicated that maternal and foetal components of the placenta respond differently to a deleterious conceptus mutation.

Abstract

Intrauterine growth restriction (IUGR) is a serious pregnancy complication caused by placental insufficiency. We previously reported that truncation of MIMT1 gene exons 3 and 4 (MIMT1Del) causes IUGR in cattle. Here we investigated miRNA expression in the foetal and maternal placenta tissues of MIMT1Del/WT foetuses. Small RNA next generation sequencing and quantitative PCR revealed placental tissue-specific expression of the miR-4321, known to regulate many genes involved in early foetal development. This study also indicated that maternal and foetal components of the placenta respond differently to a deleterious conceptus mutation.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Veterinary Clinic > Department of Farm Animals
Dewey Decimal Classification:570 Life sciences; biology
630 Agriculture
Uncontrolled Keywords:Obstetrics and Gynaecology, Developmental Biology, Reproductive Medicine, Bovine foetal growth restriction; Mammals; Placenta; miRNA expression
Language:English
Date:1 October 2018
Deposited On:05 Nov 2018 17:22
Last Modified:05 Nov 2018 17:22
Publisher:Elsevier
ISSN:0143-4004
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/j.placenta.2018.09.004
PubMed ID:30316327

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Language: English
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Embargo till: 2019-10-01