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Changes in biological pathways during 6,000 years of civilization in Europe


Chekalin, Evgeny; Rubanovich, Alexandr; Tatarinova, Tatiana V; Kasianov, Artem; Bender, Nicole; Chekalina, Marina; Staub, Kaspar; Koepke, Nikola; Rühli, Frank; Bruskin, Sergey; Morozova, Irina (2019). Changes in biological pathways during 6,000 years of civilization in Europe. Molecular Biology and Evolution, 36(1):127-140.

Abstract

The beginning of civilization was a turning point in human evolution. With increasing separation from the natural environment, mankind stimulated new adaptive reactions in response to new environmental factors. In this paper, we describe direct signs of these reactions in the European population during the past 6,000 years. By comparing whole-genome data between Late Neolithic/Bronze Age individuals and modern Europeans, we revealed biological pathways that are significantly differently enriched in non-synonymous SNPs in these two groups and which therefore could be shaped by cultural practices during the past six millennia. They include metabolic transformations, immune response, signal transduction, physical activity, sensory perception, reproduction, and cognitive functions. We demonstrated that these processes were influenced by different types of natural selection. We believe that our study opens new perspectives for more detailed investigations about when and how civilization has been modifying human genomes.

Abstract

The beginning of civilization was a turning point in human evolution. With increasing separation from the natural environment, mankind stimulated new adaptive reactions in response to new environmental factors. In this paper, we describe direct signs of these reactions in the European population during the past 6,000 years. By comparing whole-genome data between Late Neolithic/Bronze Age individuals and modern Europeans, we revealed biological pathways that are significantly differently enriched in non-synonymous SNPs in these two groups and which therefore could be shaped by cultural practices during the past six millennia. They include metabolic transformations, immune response, signal transduction, physical activity, sensory perception, reproduction, and cognitive functions. We demonstrated that these processes were influenced by different types of natural selection. We believe that our study opens new perspectives for more detailed investigations about when and how civilization has been modifying human genomes.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Evolutionary Medicine
Dewey Decimal Classification:610 Medicine & health
Uncontrolled Keywords:Genetics, Ecology, Evolution, Behavior and Systematics, Molecular Biology
Language:English
Date:1 January 2019
Deposited On:01 Nov 2018 11:58
Last Modified:22 Jan 2019 02:03
Publisher:Oxford University Press
ISSN:0737-4038
OA Status:Closed
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1093/molbev/msy201
PubMed ID:30376122

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