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Proof of concept for an intracochlear acoustic receiver for use in acute large animal experiments


Pfiffner, Flurin; Prochazka, Lukas; Dobrev, Ivo; Klein, Karina; Sulser, Patrizia; Péus, Dominik; Sim, Jae; Dalbert, Adrian; Röösli, Christof; Obrist, Dominik; Huber, Alexander (2018). Proof of concept for an intracochlear acoustic receiver for use in acute large animal experiments. Sensors, 18(10):E3565.

Abstract

(1) Background: The measurement of intracochlear sound pressure (ICSP) is relevant to obtain better understanding of the biomechanics of hearing. The goal of this work was a proof of concept of a partially implantable intracochlear acoustic receiver (ICAR) fulfilling all requirements for acute ICSP measurements in a large animal. The ICAR was designed not only to be used in chronic animal experiments but also as a microphone for totally implantable cochlear implants (TICI). (2) Methods: The ICAR concept was based on a commercial MEMS condenser microphone customized with a protective diaphragm that provided a seal and optimized geometry for accessing the cochlea. The ICAR was validated under laboratory conditions and using in-vivo experiments in sheep. (3) Results: For the first time acute ICSP measurements were successfully performed in a live specimen that is representative of the anatomy and physiology of the human. Data obtained are in agreement with published data from cadavers. The surgeons reported high levels of ease of use and satisfaction with the system design. (4) Conclusions: Our results confirm that the developed ICAR can be used to measure ICSP in acute experiments. The next generation of the ICAR will be used in chronic sheep experiments and in TICI.

Abstract

(1) Background: The measurement of intracochlear sound pressure (ICSP) is relevant to obtain better understanding of the biomechanics of hearing. The goal of this work was a proof of concept of a partially implantable intracochlear acoustic receiver (ICAR) fulfilling all requirements for acute ICSP measurements in a large animal. The ICAR was designed not only to be used in chronic animal experiments but also as a microphone for totally implantable cochlear implants (TICI). (2) Methods: The ICAR concept was based on a commercial MEMS condenser microphone customized with a protective diaphragm that provided a seal and optimized geometry for accessing the cochlea. The ICAR was validated under laboratory conditions and using in-vivo experiments in sheep. (3) Results: For the first time acute ICSP measurements were successfully performed in a live specimen that is representative of the anatomy and physiology of the human. Data obtained are in agreement with published data from cadavers. The surgeons reported high levels of ease of use and satisfaction with the system design. (4) Conclusions: Our results confirm that the developed ICAR can be used to measure ICSP in acute experiments. The next generation of the ICAR will be used in chronic sheep experiments and in TICI.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Otorhinolaryngology
05 Vetsuisse Faculty > Center for Applied Biotechnology and Molecular Medicine
Dewey Decimal Classification:610 Medicine & health
Uncontrolled Keywords:Electrical and Electronic Engineering, Analytical Chemistry, Atomic and Molecular Physics, and Optics, Biochemistry, BioMEMS; acoustic receiver; auditory system; biomedical measurement; cochlea; ear; hydrophone; implantable microphone; implantable sensor; intracochlear sound pressure; sheep; totally implantable cochlear implant
Language:English
Date:21 October 2018
Deposited On:12 Nov 2018 16:37
Last Modified:01 Dec 2018 01:17
Publisher:MDPI Publishing
ISSN:1424-8220
OA Status:Gold
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.3390/s18103565
PubMed ID:30347862

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