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Multispectral Near-Infrared Optical Tomography for Cancer Hypoxia Study in Mice


Kalyanov, A; Germanier, C; Ahnen, L; Jiang, J; Lindner, S; Di Costanzo Mata, A; Sánchez Majos, S; Rudin, Markus; Wolf, M (2018). Multispectral Near-Infrared Optical Tomography for Cancer Hypoxia Study in Mice. Advances in Experimental Medicine and Biology, 1072:165-169.

Abstract

Oxygenation of a tumor is one of the most important predictive factors: hypoxia is associated with aggressive tumors and substantially lower survival rate. Despite this high relevance of tumor oxygenation, there is currently no bedside technique available to measure it in clinical routine care. The aim of this work is to determine the oxygenation of tissue in mice by a continuous wave multispectral near-infrared optical tomograph (mNIROT). Tomographic reconstructions were processed by a massively modified NIRFAST software. We quantitatively measured the tissue oxygen saturation of the tumors in 4 BALB/c nude, female mice with human colon carcinoma cancer cells DLD-1 KRAS injected subcutaneously. The study revealed changes of oxygenation in tumors on the long-term.

Abstract

Oxygenation of a tumor is one of the most important predictive factors: hypoxia is associated with aggressive tumors and substantially lower survival rate. Despite this high relevance of tumor oxygenation, there is currently no bedside technique available to measure it in clinical routine care. The aim of this work is to determine the oxygenation of tissue in mice by a continuous wave multispectral near-infrared optical tomograph (mNIROT). Tomographic reconstructions were processed by a massively modified NIRFAST software. We quantitatively measured the tissue oxygen saturation of the tumors in 4 BALB/c nude, female mice with human colon carcinoma cancer cells DLD-1 KRAS injected subcutaneously. The study revealed changes of oxygenation in tumors on the long-term.

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Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neonatology
04 Faculty of Medicine > Institute of Pharmacology and Toxicology
07 Faculty of Science > Institute of Pharmacology and Toxicology

04 Faculty of Medicine > Institute of Biomedical Engineering
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2018
Deposited On:20 Nov 2018 16:43
Last Modified:24 Sep 2019 23:52
Publisher:Springer
ISSN:0065-2598
OA Status:Closed
Publisher DOI:https://doi.org/10.1007/978-3-319-91287-5_26
PubMed ID:30178340

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