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Low serum zinc levels predict presence of depression symptoms, but not overall disease outcome, regardless of ATG16L1 genotype in Crohn's disease patients


Greuter, Thomas; Franc, Yannick; Kaelin, Matthias; Schoepfer, Alain M; Schreiner, Philipp; Zeitz, Jonas; Scharl, Michael; Misselwitz, Benjamin; Straumann, Alex; Vavricka, Stephan R; Rogler, Gerhard; von Känel, Roland; Biedermann, Luc (2018). Low serum zinc levels predict presence of depression symptoms, but not overall disease outcome, regardless of ATG16L1 genotype in Crohn's disease patients. Therapeutic Advances in Gastroenterology, 11:1756283X18757715.

Abstract

Background Zinc deficiency (ZD) in Crohn's disease (CD) is considered a frequent finding and may exacerbate CD activity. ZD is associated with depression in non-CD patients. We aimed to assess the prevalence of ZD in CD patients in clinical remission, its association with mood disturbances and to analyze a potential impact on future disease course.
Methods Zinc levels from CD patients in clinical remission at baseline and an uncomplicated disease course within the next 3 years ( = 47) were compared with those from patients developing complications ( = 50). Baseline symptoms of depression and anxiety were measured with the Hospital Anxiety and Depression scale.
Results Mean zinc level in the 97 patients (40.4 ± 15.7 years, 44.3% males) was 18.0 ± 4.7 μmol/l. While no ZD (<11 μmol/l) was observed, we found low zinc levels (<15.1 μmol/l) in 28 patients (28.9%). Males had higher zinc levels compared with females (19.4 ± 5.7 16.8 ± 3.3, = 0.006). Patients with low zinc levels more often reported depression symptoms compared with patients with higher levels (27.3 9.4%, = 0.047). In a multivariate analysis, zinc levels were an independent negative predictor for depression symptoms [odds ratio (OR) 0.727, 95% confidence interval (CI) 0.532-0.993, = 0.045]. Zinc levels of patients with a complicated disease course were not different from those of patients without (17.7 ± 4.3 18.3 ± 5.1, n.s.). Baseline zinc levels did not predict disease outcome regardless of ATG16L1 genotype.
Conclusion Low-normal zinc levels were an independent predictor for the presence of depression symptoms in CD patients. Zinc levels at baseline did not predict a complicated disease course, neither in CD patients overall, nor ATG16L1 carriers.

Abstract

Background Zinc deficiency (ZD) in Crohn's disease (CD) is considered a frequent finding and may exacerbate CD activity. ZD is associated with depression in non-CD patients. We aimed to assess the prevalence of ZD in CD patients in clinical remission, its association with mood disturbances and to analyze a potential impact on future disease course.
Methods Zinc levels from CD patients in clinical remission at baseline and an uncomplicated disease course within the next 3 years ( = 47) were compared with those from patients developing complications ( = 50). Baseline symptoms of depression and anxiety were measured with the Hospital Anxiety and Depression scale.
Results Mean zinc level in the 97 patients (40.4 ± 15.7 years, 44.3% males) was 18.0 ± 4.7 μmol/l. While no ZD (<11 μmol/l) was observed, we found low zinc levels (<15.1 μmol/l) in 28 patients (28.9%). Males had higher zinc levels compared with females (19.4 ± 5.7 16.8 ± 3.3, = 0.006). Patients with low zinc levels more often reported depression symptoms compared with patients with higher levels (27.3 9.4%, = 0.047). In a multivariate analysis, zinc levels were an independent negative predictor for depression symptoms [odds ratio (OR) 0.727, 95% confidence interval (CI) 0.532-0.993, = 0.045]. Zinc levels of patients with a complicated disease course were not different from those of patients without (17.7 ± 4.3 18.3 ± 5.1, n.s.). Baseline zinc levels did not predict disease outcome regardless of ATG16L1 genotype.
Conclusion Low-normal zinc levels were an independent predictor for the presence of depression symptoms in CD patients. Zinc levels at baseline did not predict a complicated disease course, neither in CD patients overall, nor ATG16L1 carriers.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Klinik für Konsiliarpsychiatrie und Psychosomatik
04 Faculty of Medicine > University Hospital Zurich > Clinic for Gastroenterology and Hepatology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2018
Deposited On:29 Nov 2018 16:22
Last Modified:12 Feb 2019 15:14
Publisher:Sage Publications Ltd.
ISSN:1756-283X
OA Status:Green
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1177/1756283X18757715
PubMed ID:29487628

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