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PTPN2 as a promoter of colon carcinoma via reduction of inflammasome activation


Spalinger, Marianne R; Scharl, Michael (2018). PTPN2 as a promoter of colon carcinoma via reduction of inflammasome activation. Molecular, 5(4):e1465013.

Abstract

We have recently demonstrated that macrophage-specific loss of Protein tyrosine phosphatase non-receptor type 2 (PTPN2) promotes inflammasome activation, resulting in protection from colorectal cancer. Here we place these findings in context with the role of inflammasomes in colorectal carcinoma, and with a recent study indicating that PTPN2-silencing promotes anti-cancer immunotherapy.

Abstract

We have recently demonstrated that macrophage-specific loss of Protein tyrosine phosphatase non-receptor type 2 (PTPN2) promotes inflammasome activation, resulting in protection from colorectal cancer. Here we place these findings in context with the role of inflammasomes in colorectal carcinoma, and with a recent study indicating that PTPN2-silencing promotes anti-cancer immunotherapy.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Gastroenterology and Hepatology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2018
Deposited On:30 Nov 2018 11:37
Last Modified:30 Nov 2018 11:50
Publisher:Taylor & Francis
ISSN:2372-3556
OA Status:Closed
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1080/23723556.2018.1465013
PubMed ID:30250914

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