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Advances in the Biofabrication of 3D Skin in vitro: Healthy and Pathological Models


Randall, Matthew J; Jüngel, Astrid; Rimann, Markus; Wuertz-Kozak, Karin (2018). Advances in the Biofabrication of 3D Skin in vitro: Healthy and Pathological Models. Frontiers in Bioengineering and Biotechnology, 6:154.

Abstract

The relevance for in vitro three-dimensional (3D) tissue culture of skin has been present for almost a century. From using skin biopsies in organ culture, to vascularized organotypic full-thickness reconstructed human skin equivalents, in vitro tissue regeneration of 3D skin has reached a golden era. However, the reconstruction of 3D skin still has room to grow and develop. The need for reproducible methodology, physiological structures and tissue architecture, and perfusable vasculature are only recently becoming a reality, though the addition of more complex structures such as glands and tactile corpuscles require advanced technologies. In this review, we will discuss the current methodology for biofabrication of 3D skin models and highlight the advantages and disadvantages of the existing systems as well as emphasize how new techniques can aid in the production of a truly physiologically relevant skin construct for preclinical innovation.
KEYWORDS: 3D tissue model; biofabrication; bioprinting; electrospinning; in vitro; preclinical testing; skin; skin disease

Abstract

The relevance for in vitro three-dimensional (3D) tissue culture of skin has been present for almost a century. From using skin biopsies in organ culture, to vascularized organotypic full-thickness reconstructed human skin equivalents, in vitro tissue regeneration of 3D skin has reached a golden era. However, the reconstruction of 3D skin still has room to grow and develop. The need for reproducible methodology, physiological structures and tissue architecture, and perfusable vasculature are only recently becoming a reality, though the addition of more complex structures such as glands and tactile corpuscles require advanced technologies. In this review, we will discuss the current methodology for biofabrication of 3D skin models and highlight the advantages and disadvantages of the existing systems as well as emphasize how new techniques can aid in the production of a truly physiologically relevant skin construct for preclinical innovation.
KEYWORDS: 3D tissue model; biofabrication; bioprinting; electrospinning; in vitro; preclinical testing; skin; skin disease

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Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Balgrist University Hospital, Swiss Spinal Cord Injury Center
04 Faculty of Medicine > University Hospital Zurich > Rheumatology Clinic and Institute of Physical Medicine
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Life Sciences > Biotechnology
Physical Sciences > Bioengineering
Health Sciences > Histology
Physical Sciences > Biomedical Engineering
Language:German
Date:2018
Deposited On:15 Jan 2019 15:42
Last Modified:19 Jun 2024 01:59
Publisher:Frontiers Research Foundation
ISSN:2296-4185
OA Status:Gold
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.3389/fbioe.2018.00154
PubMed ID:30430109
  • Content: Published Version
  • Licence: Creative Commons: Attribution 4.0 International (CC BY 4.0)